Results 41 to 50 of about 496,174 (254)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

open access: yesFEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin   +3 more
wiley   +1 more source

In Vitro Comparative Study of Antioxidant and Antibacterial Activity of Selected Dietary Plants

open access: yesNepal Journal of Biotechnology, 2018
Ethanolic extracts of Garlic (Bulb), Aloe (leaf), Flower bud (buds), Turmeric (rhizomes) and Ginger (rhizomes) were used for relative analysis of antioxidant and antimicrobial activity.
Ashok Kumar   +3 more
doaj   +1 more source

Color stability of a resin composite: Effect of the immersion method and surface treatments

open access: yesIndian Journal of Dental Research, 2016
Background: In vitro staining methods expose the entire specimen to staining solutions. In a real clinical situation, this is not observed, since one should consider that the bonded surface is not exposed to the oral environment.
L L Miotti   +4 more
doaj   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

open access: yesFEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata   +13 more
wiley   +1 more source

Effect of Various External Shading Devices on Windows for Minimum Heat Gain and Adequate Day lighting into Buildings of Hot and Dry Climatic Zone in India

open access: yesMATEC Web of Conferences, 2018
Glass is the major component of the building envelope to provide visual comfort to inside the buildings. In général clear and bronze glass was used as a main building envelope for both residential and commercial buildings to provide better day lighting ...
Kirankumar Gorantla   +3 more
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

open access: yesFEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão   +3 more
wiley   +1 more source

Relationship between Maternal Serum Copper Level and Birth Weight Neonate

open access: yesMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2012
Background and Objectives: Low birth weight (LBW) is a major public health problem. LBW is associated with increased neonatal morbidity and mortality.
M Mirzarahimi   +4 more
doaj  

The light stability of transparent coating materials is influenced by the location of exposition

open access: yesActa Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2010
The ultraviolet radiation (UV), reaching the earth‘s surface, changes color of the paint films. By exposure to weathering, the biggest damage is caused by light, especially short-wavelength UV, high temperature and humidity. Any of these factors can lead
Vratislav Závada
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

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