Results 151 to 160 of about 165,674 (237)

Distinct Phage‐Encoded Enzymes for Substitution of Deoxythymidine by Deoxyuridine in Phage Genomes

open access: yesAdvanced Science, EarlyView.
Distinct enzymes including dCTP deaminases (Dcds), dTMP phosphatases (Dtms), and dTTP pyrophosphatases (Dtt) are found to be responsible for dU‐DNA biosynthesis in the phages PBS1, DSS3_VP1, and PhiR1‐37. Both PhiR1‐37‐derived and synthetic dU‐DNA are resistant to cleavage by restriction enzymes and Cas12a nuclease targeting dT‐containing sites.
Yating Li   +7 more
wiley   +1 more source

Anti‐Swelling Hydrogel Combined With Nucleus Pulposus Cell Exosomes and Senolytic Drugs Efficiently Repair Intervertebral Disc Degeneration

open access: yesAdvanced Science, EarlyView.
In this study, a bifunctional anti‐swelling hydrogel system is developed, which encapsulated anti‐senescence drugs quercetin, dasatinib, nucleus pulposus‐derived exosomes (NP‐Exo) to clear senescent nucleus pulposus cells, regulate the inflammatory disc microenvironment, and enhance nucleus pulposus cells activity, ultimately promoting the repair of ...
Songfeng Chen   +14 more
wiley   +1 more source

Lactobacillus Salivarius‐Derived Indole‐3‐Acetic Acid Promotes AHR‐PARP1 Axis‐Mediated DNA Repair to Mitigate Intestinal Aging

open access: yesAdvanced Science, EarlyView.
Indole‐3‐acetic acid (IAA) acting as one of the aryl hydrocarbon receptor (AHR) endogenous ligands is identified to be derived from Lactobacillus salivarius via its catalytic enzyme (ALDH) rather than host cells. Lactobacillus salivarius and IAA supplementation effectively mitigate intestinal aging by facilitating AHR‐poly (ADP‐ribose) polymerase 1 ...
Zheng Cao   +13 more
wiley   +1 more source

Ultrafast Dynamics of Electronic and Structural Modifications Induced by Photoexcitation in Cerium Oxide

open access: yesAdvanced Electronic Materials, EarlyView.
The ultrafast dynamics of electronic and atomic structural evolution following band‐gap photoexcitation in a cerium oxide film are investigated using pump–probe X‐ray absorption near‐edge spectroscopy and etended X‐ray absorption fine structure at the European X‐ray Free Electron Laser.
Samuele Pelatti   +22 more
wiley   +1 more source

Recent Progress on Photoelectrochemical Organic Upgrading: A Review from Direct and Indirect Charge Transfer Pathway

open access: yesAdvanced Energy Materials, EarlyView.
Photoelectrochemical (PEC) organic upgrading at the anode, coupled with hydrogen evolution at the cathode, presents a promising strategy for enhancing solar energy utilization while simultaneously generating value‐added chemicals. An overview of directional photoanodic conversion of organic substrates is presented, distinctively with an eye to the ...
Cheng Lin   +3 more
wiley   +1 more source

Active Transport of Macrocycles into Micelles Using Molecular Pumps

open access: yesAngewandte Chemie, EarlyView.
Artificial molecular pumps attached to polymeric micelles were found capable of transporting charged macrocycles into the micelles. The pumps operate with only modestly reduced pumping efficiency as compared to nonmicellar counterparts, indicating that ring‐threading molecular pumps can transport charged solutes into supramolecular assemblies, akin to ...
James S. W. Seale   +17 more
wiley   +2 more sources

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