Results 41 to 50 of about 196,486 (266)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Synthesis, spectral and thermo-kinetics explorations of Schiff-base derived metal complexes

Open Chemistry, 2020
Schiff-base ligand, 2,6-bis(benzimino)-4-phenyl-1,3,5-triazine (L), and its transition metal complexes of Co(ii), Ni(ii), and Cu(ii) were synthesized by refluxing the reaction mixture and its analytical, spectral, and thermogravimetric characteristics ...
Ahmad Naushad, Alam Manawwer, Wahab Rizwan, Ahmed Mukhtar, Ahmad Ashfaq   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Phytoconstituents profiling of indigenous herbal drugs and its in vitro microbial, in silico biological examination against Severe acute respiratory syndrome coronavirus 2

World Journal of Traditional Chinese Medicine
Background: Habb-E-Shifa, Hamdard Sualin, and Hamdard Joshanda traditional herbal medicines may promote host resistance against infection by bacteria, viruses, and fungi which are easily accessible at inexpensive with no complexity.
T H. Mohamed Ahadu Shareef, M Mohamed Divan Masood, Irfan Navabshan, M Saiyad Musthafa   +3 more
doaj   +1 more source

Sharp Polarimetric Eyes: More Trees than Forest?

Galaxies, 2016
The Fermi Gamma-ray Space Telescope (Fermi) has focused the intensive multi-wavelength and international observational effort on blazars since it was launched in 2008. Part of this effort involves systematic monitoring of the highly variable polarization
Paul S. Smith
doaj   +1 more source

Spectroscopic studies of AFP, Anti AFP antibody and AFP/125I- anti AFP antibody complex. [PDF]

مجلة جامعة الانبار للعلوم الصرفة, 2014
The aim of this work is to characterize spectrophotometrically the isolated Alpha fetoprotein from human colorectal tumor homogenates and the molecules of both AFP antibody and the complex of AFP/anti AFP antibody.Gel filtration technique was used to ...
Bilal Jasir Mohammed, Sami A Al Mudhaffar, Hathama R Hassan   +2 more
doaj   +1 more source