Results 111 to 120 of about 3,143,049 (329)

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Compressive Fourier Transform Spectroscopy

, 2010
We describe an approach based on compressive-sampling which allows for a considerable reduction in the acquisition time in Fourier-transform spectroscopy.
Katz, Ori, Levitt, Jonathan M., Silberberg, Yaron   +2 more
core   +1 more source

Measurement of Temperatures in Flames of Complex Structure by Resonance Line Radiation. II. Sodium Line Reversal by High-Resolution Spectroscopy [PDF]

, 1954
H. M. Strong, F. P. Bundy
openalex   +1 more source

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source

Identifying prognostic targets in metastatic prostate cancer beyond AR

FEBS Open Bio, EarlyView.
Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng, Eric Feng, Tracy Berg, Isabella S. Nguyen, Lilac G. Nguyen, William Chen, Meng Zhang, David Quigley, Marina Sharifi, Haolong Li, Ilsa Coleman, Peter S. Nelson, Martin Sjöström, Shuang G. Zhao   +13 more
wiley   +1 more source

Structural and time-domain peculiarities of the fluorescence excitation spectra of single Mg-TAP in a polymer at low temperatures

EPJ Web of Conferences, 2018
The results of low-temperature measurements of spectral trails (temporal evolutions of individual fluorescence excitation spectra) of single molecules Mg-tetraazaporphyrin embedded in polyisobutylene are presented.
Savostianov Aleksandr, Eremchev Ivan, Gorshelev Alexei, Orlov Sergei, Korotayev Oleg, Naumov Andrei, Starukhin Aleksandr   +6 more
doaj   +1 more source

Seesaw Spectroscopy at Colliders [PDF]

, 2011
A low-scale neutrino seesaw may be probed or even reconstructed at colliders provided that supersymmetry is at the weak scale and the LSP is a sterile sneutrino. Because the neutrino Yukawa couplings are small, the NLSP is typically long-lived and thus a
Cheung, Clifford, Hall, Lawrence J., Pinner, David   +2 more
core   +1 more source

Microwave Spectroscopy [PDF]

, 1955

openalex   +1 more source

Interaction of class III cellobiose dehydrogenase with lytic polysaccharide monooxygenase

FEBS Open Bio, EarlyView.
The activity of lytic polysaccharide monooxygenase (LPMO) is supported by its auxiliary enzyme cellobiose dehydrogenase (CDH). The catalytic activity of both enzymes is coupled by electron transfer and a cyclic cascade generating substrates for both enzymes – hydrogen peroxide for LPMO and oxidized and non‐oxidized cellobiose and cello‐oligosaccharide ...
Angela Giorgianni, Florian Csarman, Peicheng Sun, Mirjam Kabel, Roland Ludwig   +4 more
wiley   +1 more source