Results 91 to 100 of about 2,074,156 (315)
Fractional Deuteration applied to biomolecular solid-state NMR spectroscopy [PDF]
, 2011 Solid-state Nuclear Magnetic Resonance can provide detailed insight into structural and dynamical aspects of complex biomolecules. With increasing molecular size, advanced approaches for spectral simplification and the detection of medium to long-range ...
NMR Spectroscopy +10 more
core +2 more sources
MoleculesThis investigation focused on isoniazid (INH)—saccharin (SAC) salts. One hydrate and one anhydrous INH-SAC salt form were synthesized and characterized spectroscopically by Raman and infrared spectroscopy.
Rezvan Mohammadi +5 more
doaj +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
NMR-based structural biology of microtubules and of microtubule-associated proteins [PDF]
, 2019 The dynamic instability of microtubules (MT) is an essential feature in eukaryotic cells and related to basic cellular processes such as intracellular transport, cell division, migration, or polarization.
NMR Spectroscopy +2 more
core
, 2014 The direct combination of chemometrics and two-dimensional (2D) correlation spectroscopy is considered. The use of a reconstructed data matrix based on the significant scores and loading vectors obtained from the principal component analysis (PCA) of raw
Shin, HS +4 more
core +1 more source
Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers
FEBS Letters, EarlyView.Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui +4 more
wiley +1 more source
Dissecting Biomolecular Interactions by Integrative Modeling [PDF]
, 2013 Proteins and their intricate network of interactions are the mainstay of any cellular process. Dissecting their interaction networks at atomic detail is therefore invaluable, as this will pave the route to a mechanistic understanding of biological ...
NMR Spectroscopy +2 more
core +1 more source
Electron-nuclear correlated multiphoton-route to Rydberg fragments of molecules
Nature Communications, 2019 Rydberg atoms can be created from photoexcitation of molecules using intense ultrafast laser pulses. Here the authors use a coincidence detection of electrons, ion and excited Rydberg atoms and their energy sharing to reveal the general mechanism of ...
Wenbin Zhang +11 more
doaj +1 more source
The Journal of Physical Chemistry Letters, 2015 Spectroscopic analysis and study of nanoparticle samples is often hampered by structural diversity that presents a complex superposition of spectral signatures. By probing the spectra of small volumes within dilute samples, we can expose statistical variations in composition to obtain information unavailable from bulk spectroscopy. This new approach is
Streit, Jason K. +4 more
openaire +3 more sources
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source