Results 71 to 80 of about 1,750,612 (319)
Nature Communications, 2022 By using laser tweezers, the authors show that a single α-catenin molecule does not resist force on F-actin. However, clustering of multiple molecules and force applied toward F-actin pointed end engage a molecular switch in α-catenin, which unfolds and ...
C. Arbore +8 more
doaj +1 more source
NMR characterization of foldedness for the production of E3 RING domains
, 2010 We summarize the use of NMR spectroscopy in the production and the screening of stability and foldedness of protein domains, and apply it to the RING domains of E3 ubiquitin-ligases.
NMR Spectroscopy +6 more
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
, 2014 The direct combination of chemometrics and two-dimensional (2D) correlation spectroscopy is considered. The use of a reconstructed data matrix based on the significant scores and loading vectors obtained from the principal component analysis (PCA) of raw
Shin, HS +4 more
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Selective Membrane Transport Systems studied by Solid-State NMR Spectroscopy
, 2009 Membranes border cells from their environment. Thus, they belong to the basic prerequisites for life as we know it. Within cells, membranes are used to establish compartments dedicated to specific tasks such as providing local proximity of components ...
Ader, C. +3 more
core
The Study of Oil Film Thickness Measurement on Water Surface Based on Laser Raman Spectroscopy
, 2018 In order to realize the fast and non-contact detection of oil film thickness on water surface, a system based on laser Raman spectroscopy technologywas introduced in this paper. The 532 nm laser was used as the exciting source, and the result shows there
Feng Wei-wei +2 more
core +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Electron-nuclear correlated multiphoton-route to Rydberg fragments of molecules
Nature Communications, 2019 Rydberg atoms can be created from photoexcitation of molecules using intense ultrafast laser pulses. Here the authors use a coincidence detection of electrons, ion and excited Rydberg atoms and their energy sharing to reveal the general mechanism of ...
Wenbin Zhang +11 more
doaj +1 more source