Results 61 to 70 of about 1,750,612 (319)

Complex Formation and Light Activation in Membrane-Embedded Sensory Rhodopsin II as Seen by Solid-State NMR Spectroscopy

, 2010
Microbial rhodopsinsexecutediverse biological functions in the cellular membrane. A mechanistic understanding of their functional profile is, however, still limited.
Li, Lin, Geyer, Matthias, Etzkorn, M., Etzkorn, Manuel, Seidel, Karsten, Sub NMR Spectroscopy, Geyer, M., Engelhard, Martin, Martell, Swetlana, Baldus, Marc, NMR Spectroscopy, Baldus, M., Seidel, K., Engelhard, M., Martell, S., Li, L.   +15 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Long-term cargo tracking reveals intricate trafficking through active cytoskeletal networks in the crowded cellular environment

Nature Communications, 2023
A eukaryotic cell is a microscopic world within which efficient material transport is essential. Yet, how a cell manages to deliver cellular cargos efficiently in a crowded environment remains poorly understood.
Jin-Sung Park, Il-Buem Lee, Hyeon-Min Moon, Seok-Cheol Hong, Minhaeng Cho   +4 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Evaluating pathological levels of intracellular cholesterol through Raman and surface-enhanced Raman spectroscopies

Scientific Reports
Versatile methods for the quantification of intracellular cholesterol are essential for understanding cellular physiology and for diagnosing disorders linked to cholesterol metabolism.
Enrico Baria, Caterina Dallari, Francesco Mattii, Francesco Saverio Pavone, Caterina Credi, Riccardo Cicchi, Amelia Morrone, Claudia Capitini, Martino Calamai   +8 more
doaj   +1 more source

Formation of the β-barrel assembly machinery complex in lipid bilayers as seen by solid-state NMR

Nature Communications, 2018
The β-barrel assembly machinery (BAM) catalyzes β-barrel protein insertion into the outer membrane of E.coli. Here authors employ high-sensitivity solid-state NMR to reveal how the lipid environment and formation of the BamA-BamCDE complex affect BamA ...
Cecilia Pinto, Deni Mance, Tessa Sinnige, Mark Daniëls, Markus Weingarth, Marc Baldus   +5 more
doaj   +1 more source

Measurements of collisional broadening coefficients by infrared polarization spectroscopy

, 2007
We present measurements of collisional broadening coefficients, obtained at atmospheric pressure, by polarization spectroscopy. Using tunable single mode laser radiation at approximately 2 microm, high-resolution infrared polarization spectra were ...
Zetterberg, Johan,, Aldén, Marcus,, Zetterberg, Johan, Zetterberg, J., Alwahabi, Z., Li, Z., Li, Zhongshan, Li, Zhongshan,, Lund University., Alden, M., Alwahabi, Z. T., Aldén, Marcus   +11 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Ultrafast photoinduced C-H bond formation from two small inorganic molecules

Nature Communications
The formation of carbon-hydrogen (C-H) bonds via the reaction of small inorganic molecules is of great significance for understanding the fundamental transition from inorganic to organic matter, and thus the origin of life. Yet, the detailed mechanism of
Zhejun Jiang, Hao Huang, Chenxu Lu, Lianrong Zhou, Shengzhe Pan, Junjie Qiang, Menghang Shi, Zhengjun Ye, Peifen Lu, Hongcheng Ni, Wenbin Zhang, Jian Wu   +11 more
doaj   +1 more source