Results 61 to 70 of about 2,859,006 (301)

Long-term cargo tracking reveals intricate trafficking through active cytoskeletal networks in the crowded cellular environment

Nature Communications, 2023
A eukaryotic cell is a microscopic world within which efficient material transport is essential. Yet, how a cell manages to deliver cellular cargos efficiently in a crowded environment remains poorly understood.
Jin-Sung Park, Il-Buem Lee, Hyeon-Min Moon, Seok-Cheol Hong, Minhaeng Cho   +4 more
doaj   +1 more source

Multichannel spectroscopy guide [PDF]

, 1969
System makes use of diverging duct walls for conducting the light from entrance slips to the conductors by means of multiple reflectors. This system simultaneously records, photoelectrically, the intensities of several closely spaceed narrow wavelengths ...
Roth, D. E., Rothe, D. E.
core   +1 more source

Reflectance Spectroscopy [PDF]

Gastrointestinal Endoscopy Clinics of North America, 2009
Reflectance spectroscopy is an emerging technology which provides rapid and safe evaluation of tissue for dysplasia and ischemia. The probe-based devices can be passed through most endoscopes. Current applications include detection of dysplasia in Barrett's esophagus, colitis, and colon polyps.
Michael B, Wallace, Adam, Wax, David N, Roberts, Robert N, Graf   +3 more
openaire   +2 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Evaluating pathological levels of intracellular cholesterol through Raman and surface-enhanced Raman spectroscopies

Scientific Reports
Versatile methods for the quantification of intracellular cholesterol are essential for understanding cellular physiology and for diagnosing disorders linked to cholesterol metabolism.
Enrico Baria, Caterina Dallari, Francesco Mattii, Francesco Saverio Pavone, Caterina Credi, Riccardo Cicchi, Amelia Morrone, Claudia Capitini, Martino Calamai   +8 more
doaj   +1 more source

Formation of the β-barrel assembly machinery complex in lipid bilayers as seen by solid-state NMR

Nature Communications, 2018
The β-barrel assembly machinery (BAM) catalyzes β-barrel protein insertion into the outer membrane of E.coli. Here authors employ high-sensitivity solid-state NMR to reveal how the lipid environment and formation of the BamA-BamCDE complex affect BamA ...
Cecilia Pinto, Deni Mance, Tessa Sinnige, Mark Daniëls, Markus Weingarth, Marc Baldus   +5 more
doaj   +1 more source

α-catenin switches between a slip and an asymmetric catch bond with F-actin to cooperatively regulate cell junction fluidity

Nature Communications, 2022
By using laser tweezers, the authors show that a single α-catenin molecule does not resist force on F-actin. However, clustering of multiple molecules and force applied toward F-actin pointed end engage a molecular switch in α-catenin, which unfolds and ...
C. Arbore, M. Sergides, L. Gardini, G. Bianchi, A. V. Kashchuk, I. Pertici, P. Bianco, F. S. Pavone, M. Capitanio   +8 more
doaj   +1 more source

Relic Neutrino Absorption Spectroscopy [PDF]

, 2004
Resonant annihilation of extremely high-energy cosmic neutrinos on big-bang relic anti-neutrinos (and vice versa) into Z-bosons leads to sizable absorption dips in the neutrino flux to be observed at Earth.
A. Blanchard, A.D. Dolgov, A.R. Jacobson, A.W. Blain, Andreas Ringwald, B. Kayser, B.P. Konstantinov, Birgit Eberle, C. Spiering, C. Weinheimer, C. Weinheimer, C.E. Aalseth, C.E. Aalseth, D. Fargion, D.N. Spergel, D.S. Gorbunov, D.V. Semikoz, D.V. Semikoz, E. Roulet, F. Feruglio, F. Feruglio, G.T. Zatsepin, H. Athar, H. Päs, H.V. Klapdor-Kleingrothaus, H.V. Klapdor-Kleingrothaus, H.V. Klapdor-Kleingrothaus, J. Bernstein, J.F. Beacom, J.F. Beacom, J.G. Learned, J.N. Bahcall, K. Greisen, K. Hagiwara, K. Mannheim, K. Mannheim, K.N. Abazajian, L. Bento, L.A. Anchordoqui, Liguo Song, M. Tegmark, N. Gehrels, N.G. Lehtinen, O. Elgaroy, O.E. Kalashev, O.E. Kalashev, P. Bhattacharjee, P. Chen, P. Gondolo, P. Gorham, P. Madau, P. Palunas, P. Singh, P. Sreekumar, P.P. Kronberg, R. Aloisio, R. Cowsik, R. Gandhi, R. Gandhi, R. Wigmans, R.M. Baltrusaitis, S. Davidson, S. Hannestad, S. Kazantzidis, S. Nussinov, S. Yoshida, S. Yoshida, S. Yoshida, S. Yoshida, S.D. Wick, S.M. Bilenky, S.W. Allen, T. Hara, T. Hara, T.J. Weiler, T.J. Weiler, T.J. Weiler, Thomas J. Weiler, U. Keshet, V. Barger, V. Berezinsky, V. Berezinsky, V.D. Barger, V.H. Regener, V.M. Lobashev, V.S. Berezinsky, V.S. Berezinsky, V.S. Berezinsky, W. Hu, X. Bertou, Y.Y. Wong, Z. Fodor, Z. Fodor, Z. Fodor, Z. Fodor, Z. Fodor   +95 more
core   +1 more source