Results 51 to 60 of about 1,750,612 (319)

ADVANCED OPTICAL TECHNIQUES TO EXPLORE BRAIN STRUCTURE AND FUNCTION [PDF]

Journal of Innovative Optical Health Sciences, 2013
Understanding brain structure and function, and the complex relationships between them, is one of the grand challenges of contemporary sciences. Thanks to their flexibility, optical techniques could be the key to explore this complex network.
L. SILVESTRI, A. L. ALLEGRA MASCARO, J. LOTTI, L. SACCONI, F. S. PAVONE   +4 more
doaj   +1 more source

Characterization of a Cyclic Nucleotide-Activated K+ Channel and its Lipid Environment by Using Solid-State NMR Spectroscopy

, 2013
Voltage-gated ion channels are large tetrameric multidomain membrane proteins that play crucial roles in various cellular transduction pathways. Because of their large size and domain-related mobility, structural characterization has proved challenging ...
NMR Spectroscopy, Baldus, M., Cukkemane, A.A., Sub NMR Spectroscopy   +3 more
core   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Dynamic Nuclear Polarization NMR Spectroscopy: Revealing Multiple Conformations in Lipid-Anchored Peptide Vaccines

, 2013
Sensitivity is the key: Dynamic nuclear polarization NMR spectroscopy provides structural information on liposomal vaccines targeting Alzheimer's disease. DMPC/DMPG/Cholesterol mainly stabilizes extended structures of the lipid-anchored peptide, while in
Koers, E.J., López-Deber, M.P., Muhs, A., Reis, P., Nand, D., Sub NMR Spectroscopy, Granet, A., NMR Spectroscopy, Baldus, M., Mlaki Ndao, D., Weingarth, M.H., Pfeifer, A., Hickman, D.T.   +12 more
core   +1 more source

Variance Spectroscopy

The Journal of Physical Chemistry Letters, 2015
Spectroscopic analysis and study of nanoparticle samples is often hampered by structural diversity that presents a complex superposition of spectral signatures. By probing the spectra of small volumes within dilute samples, we can expose statistical variations in composition to obtain information unavailable from bulk spectroscopy. This new approach is
Streit, Jason K., Bachilo, Sergei M., Sanchez, Stephen R., Lin, Ching-Wei, Weisman, R. Bruce   +4 more
openaire   +3 more sources

SIMP spectroscopy [PDF]

Journal of High Energy Physics, 2016
We study the interactions between strongly interacting massive particle dark matter and the Standard Model via a massive vector boson that is kinetically mixed with the hypercharge gauge boson. The relic abundance is set by 3-to-2 self-interactions of the dark matter, while the interactions with the vector mediator enable kinetic equilibrium between ...
Hochberg, Yonit, Kuflik, Eric, Murayama, Hitoshi   +2 more
openaire   +2 more sources

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Highly inclined light sheet allows volumetric super-resolution imaging of efflux pumps distribution in bacterial biofilms

Scientific Reports
Bacterial biofilms are highly complex communities in which isogenic bacteria display different gene expression patterns and organize in a three-dimensional mesh gaining enhanced resistance to biocides.
T. Vignolini, M. Capitanio, C. Caldini, L. Gardini, F. S. Pavone   +4 more
doaj   +1 more source

Mid-infrared pumped laser-induced thermal grating spectroscopy for detection of acetylene in the visible spectral range [PDF]

, 2016
We present mid-infrared laser-induced thermal grating spectroscopy (IR-LITGS) using excitation radiation around 3 μm generated by a simple broadband optical parametric oscillator (OPO).
Aldén, Marcus,, Sahlberg, Anna Lena, Kiefer, Johannes, Sahlberg, Anna Lena,, Li, Zhongshan, Li, Zhongshan,, Kiefer, Johannes,, Lund University., Aldén, Marcus   +8 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source