Results 41 to 50 of about 2,155,894 (257)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

All-optical field-free three-dimensional orientation of asymmetric-top molecules

Nature Communications, 2018
Alignment and orientation of the molecules allows studying the photon-molecule interactions in greater detail. Here the authors demonstrate the three-dimensional orientation of SO2 molecules in using COLTRIMS and orthogonally polarized laser pulses but ...
Kang Lin, Ilia Tutunnikov, Junjie Qiang, Junyang Ma, Qiying Song, Qinying Ji, Wenbin Zhang, Hanxiao Li, Fenghao Sun, Xiaochun Gong, Hui Li, Peifen Lu, Heping Zeng, Yehiam Prior, Ilya Sh. Averbukh, Jian Wu   +15 more
doaj   +1 more source

Single-shot imaging of surface molecular ionization in nanosystems

Nanophotonics, 2021
Using single-shot velocity map imaging technique, explosion imaging of different ion species ejected from 50 nm SiO2 nanoparticles are obtained excitedly by strong near-infrared and ultraviolet femtosecond laser fields.
Sun Fenghao, Li Hui, Song Shanshan, Chen Fei, Wang Jiawei, Qu Qiwen, Lu Chenxu, Ni Hongcheng, Wu Botao, Xu Hongxing, Wu Jian   +10 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Nanoconstructions on the base of double-stranded DNA molecules and their optical properties

EPJ Web of Conferences, 2017
Experimental results have been presented on studying optical properties of nanoconstructions formed of orientationally ordered neighbouring double-stranded DNA molecules in the structure of their liquid-crystalline phases and dispersion particles of ...
Skuridin S.G., Yevdokimov Yu.M., Chulkov D.P., Gusev V.M., Kompanets O.N., Vereschagin F.V.   +5 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Encoding terahertz holographic bits with a computer-generated 3D-printed phase plate

Scientific Reports
A sub-terahertz holographic image of a two-dimensional 576-bit data code is produced using a diffractive phase-plate element. The phase plate was designed using a modified Gerchberg-Saxton iterative algorithm to encode a focused image of the data code ...
E. Constable, J. Gospodaric, A. Pimenov
doaj   +1 more source

Optical inter-site spin transfer probed by energy and spin-resolved transient absorption spectroscopy

Nature Communications, 2020
Optically driven spin transfer is the fastest process to manipulate magnetism. Here, the authors show that this process emerges as the dominant mechanism in femtosecond spin dynamics enabling to the engineering of functional magnetic systems for future ...
Felix Willems, Clemens von Korff Schmising, Christian Strüber, Daniel Schick, Dieter W. Engel, J. K. Dewhurst, Peter Elliott, Sangeeta Sharma, Stefan Eisebitt   +8 more
doaj   +1 more source

ADVANCED OPTICAL TECHNIQUES TO EXPLORE BRAIN STRUCTURE AND FUNCTION [PDF]

Journal of Innovative Optical Health Sciences, 2013
Understanding brain structure and function, and the complex relationships between them, is one of the grand challenges of contemporary sciences. Thanks to their flexibility, optical techniques could be the key to explore this complex network.
L. SILVESTRI, A. L. ALLEGRA MASCARO, J. LOTTI, L. SACCONI, F. S. PAVONE   +4 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source