Results 81 to 90 of about 1,750,612 (319)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

New approach to generalized two-dimensional correlation spectroscopy. II: Eigenvalue manipulation transformation (EMT) for noise suppression

, 2019
This paper introduces the concept of eigenvalue manipulating transformation (EMT) of a data matrix for noise suppression in two-dimensional (2D) correlation spectroscopy.
Kim, SB, Jung, YM, Noda, I
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Application of Micro-Raman Spectroscopy to the Study of Yttria-Stabilized Tetragonal Zirconia Polycrystal (Y-TZP) Phase Transformation

, 2015
The aim of this study was to perform micro-Raman spectroscopy as an alternative and nondestructive method to identify the phase transformation of zirconia after mechanical stress.
Fracisconi, Paulo Afonso Silveira, Ramos, Carla MüeIler, Borges, Ana Flávia Sanches, Tabata, Américo Sheitiro [UNESP], Cesar, Paulo Francisco, Rubo, José Henrique, Tabata, Américo Sheitiro   +6 more
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Fractional Deuteration applied to biomolecular solid-state NMR spectroscopy [PDF]

, 2011
Solid-state Nuclear Magnetic Resonance can provide detailed insight into structural and dynamical aspects of complex biomolecules. With increasing molecular size, advanced approaches for spectral simplification and the detection of medium to long-range ...
NMR Spectroscopy, Baldus, M., Cukkemane, A.A., Deepak Nand, Abhishek Cukkemane, Nand, D., Becker, S., Stefan Becker, Sub NMR Spectroscopy, Cukkemane, A., Marc Baldus   +10 more
core   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Non-cascade random walks in solid-state high harmonic generation

Nature Communications
Random walks—both classical and quantum—unlocked new possibilities in search algorithms and information processing. Although linear photonic systems, with flexible tunability and multiple degrees of freedom, have served as efficient carriers for random ...
Zitan Zuo, Yiwen Wang, Shengzhe Pan, Lulu Han, Yidan Xu, Dian Wu, Shicheng Jiang, Jian Wu   +7 more
doaj   +1 more source

Local-Field Effects in the Zero-Phonon Spectral Lines of Single Impurity Molecules in Solid Matrices at Low Temperatures

EPJ Web of Conferences, 2015
In this work, we study the relation between the widths of the zero-phonon lines (ZPL) of single impurity molecules (SM) in solid matrices with local effective values of the refractive index n.
Anikushina T.A., Gladush M.G., Gorshelev A.A., Naumov A.V.   +3 more
doaj   +1 more source

Infrared Spectroscopy for Online Measurement of Tars, Water, and Permanent Gases in Biomass Gasification

, 2021
Online measurements of the raw gas composition, including tars and water, during biomass gasification provide valuable information in fundamental investigations and for process control.
Pushp, Mohit, Davidsson, Kent,, Brackmann, Christian, Davidsson, Kent, Pushp, Mohit,, Brackmann, Christian,, Davidsson, K., Brackmann, C.   +7 more
core   +1 more source