Results 81 to 90 of about 2,074,156 (315)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Transmission Near-Infrared (NIR) and Photon Time-of-Flight (PTOF) Spectroscopy in a Comparative Analysis of Pharmaceuticals. [PDF]

, 2015
We present a comprehensive study of the application of photon time-of-flight spectroscopy (PTOFS) in the wavelength range 1050– 1350 nm as a spectroscopic technique for the evaluation of the chemical composition and structural properties of ...
Kamran, Faisal, Svensson, Olof, Abildgaard, Otto H. A.,, Johansson, Jonas, Sparen, Anders,, Andersen, Peter E.,, Andersen, Peter E., Kamran, Faisal,, Sparén, Anders, Khoptyar, Dmitry, Abildgaard, Otto H. A., Andersson-Engels, Stefan,, Abildgaard, Otto Højager Attermann, Johansson, Jonas,, Khoptyar, Dmitry,, Svensson, Olof,, Lund University., Andersson-Engels, Stefan   +17 more
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Ultrafast photoinduced C-H bond formation from two small inorganic molecules

Nature Communications
The formation of carbon-hydrogen (C-H) bonds via the reaction of small inorganic molecules is of great significance for understanding the fundamental transition from inorganic to organic matter, and thus the origin of life. Yet, the detailed mechanism of
Zhejun Jiang, Hao Huang, Chenxu Lu, Lianrong Zhou, Shengzhe Pan, Junjie Qiang, Menghang Shi, Zhengjun Ye, Peifen Lu, Hongcheng Ni, Wenbin Zhang, Jian Wu   +11 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

DNP-Supported Solid-State NMR Spectroscopy of Proteins Inside Mammalian Cells [PDF]

, 2019
Elucidating at atomic level how proteins interact and are chemically modified in cells represents a leading frontier in structural biology. We have developed a tailored solid-state NMR spectroscopic approach that allows studying protein structure inside ...
Sub NMR Spectroscopy, Narasimhan, Siddarth, Folkers, Gert E., Paioni, A.L., Johan van der Zwan, Scherpe, Stephan, Ovaa, H., Marc Baldus, Gert E. Folkers, Baldus, Marc, NMR Spectroscopy, Scherpe, S., Folkers, G.E., Baldus, M., Alessandra Lucini Paioni, Narasimhan, S., Lucini Paioni, Alessandra, Stephan Scherpe, Huib Ovaa, van der Zwan, Johan, Siddarth Narasimhan, Zwan, J. van der, Ovaa, Huib   +22 more
core   +2 more sources

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Data-driven docking for the study of biomolecular complexes [PDF]

, 2005
With the amount of genetic information available, a lot of attention has focused on systems biology, in particular biomolecular interactions. Considering the huge number of such interactions, and their often weak and transient nature, conventional ...
Boelens, Rolf, NMR Spectroscopy, Bonvin, Alexandre M. J. J., Sub NMR Spectroscopy, Van Dijk, Aalt D. J.   +4 more
core   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

The Study of Oil Film Thickness Measurement on Water Surface Based on Laser Raman Spectroscopy

, 2018
In order to realize the fast and non-contact detection of oil film thickness on water surface, a system based on laser Raman spectroscopy technologywas introduced in this paper. The 532 nm laser was used as the exciting source, and the result shows there
Feng Wei-wei, Cai Zong-qi, Wang Chuan-yuan   +2 more
core   +1 more source