Results 81 to 90 of about 2,155,894 (257)

Interpretable Deep Supramolecular Language Modeling for Cocrystal Design: PCA-Augmented DeepCocrystal Screening of Picolinamide, Nicotinamide, and Isonicotinamide Systems

Molecules
Cocrystallization is an effective strategy for modifying the physicochemical properties of active pharmaceutical ingredients (APIs), yet rational coformer selection remains challenging. In this work, we propose an interpretable extension of DeepCocrystal
Bahadır Bozkurt, Ayberk Yilmaz, Gulce Ogruc Ildiz, Rui Fausto   +3 more
doaj   +1 more source

Electron-nuclear correlated multiphoton-route to Rydberg fragments of molecules

Nature Communications, 2019
Rydberg atoms can be created from photoexcitation of molecules using intense ultrafast laser pulses. Here the authors use a coincidence detection of electrons, ion and excited Rydberg atoms and their energy sharing to reveal the general mechanism of ...
Wenbin Zhang, Xiaochun Gong, Hui Li, Peifen Lu, Fenghao Sun, Qinying Ji, Kang Lin, Junyang Ma, Hanxiao Li, Junjie Qiang, Feng He, Jian Wu   +11 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Proceedings of the Thirteenth International Conference on Time-Resolved Vibrational Spectroscopy [PDF]

, 2007
The thirteenth meeting in a long-standing series of “Time-Resolved Vibrational Spectroscopy” (TRVS) conferences was held May 19th to 25th at the Kardinal Döpfner Haus in Freising, Germany, organized by the two Munich Universities - Ludwig-Maximilians ...
Laubereau, Alfred
core   +1 more source

Array detection enables large localization range for simple and robust MINFLUX

Light: Science & Applications
The MINFLUX concept significantly improves the localization properties of single-molecule localization microscopy (SMLM) by overcoming the limit imposed by the fluorophore’s photon counts.
Eli Slenders, Sanket Patil, Marcus Oliver Held, Alessandro Zunino, Giuseppe Vicidomini   +4 more
doaj   +1 more source

Generation of 22-mJ, 2.0-ps Pulses from a 1-kHz Ho:YLF Regenerative Chirped Pulse Amplifier [PDF]

EPJ Web of Conferences
We report a CW-pumped Ho:YLF regenerative amplifier (RA) delivering pulses with 22.5-mJ energy and 2.0-ps duration at 1 kHz. The RA emitting at 2051 nm is broadband-seeded and implemented in a chirped pulse amplification system. © 2024 The Author(s)
Bock Martin, von Grafenstein Lorenz, Mero Mark, Nagy Tamas, Griebner Uwe   +4 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Non-cascade random walks in solid-state high harmonic generation

Nature Communications
Random walks—both classical and quantum—unlocked new possibilities in search algorithms and information processing. Although linear photonic systems, with flexible tunability and multiple degrees of freedom, have served as efficient carriers for random ...
Zitan Zuo, Yiwen Wang, Shengzhe Pan, Lulu Han, Yidan Xu, Dian Wu, Shicheng Jiang, Jian Wu   +7 more
doaj   +1 more source

Local-Field Effects in the Zero-Phonon Spectral Lines of Single Impurity Molecules in Solid Matrices at Low Temperatures

EPJ Web of Conferences, 2015
In this work, we study the relation between the widths of the zero-phonon lines (ZPL) of single impurity molecules (SM) in solid matrices with local effective values of the refractive index n.
Anikushina T.A., Gladush M.G., Gorshelev A.A., Naumov A.V.   +3 more
doaj   +1 more source