Results 91 to 100 of about 19,025 (294)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Linear and nonlinear abstract differential equations of high order

Open Mathematics, 2015
The nonlocal boundary value problems for linear and nonlinear degenerate abstract differential equations of arbitrary order are studied. The equations have the variable coefficients and small parameters in principal part.
Shakhmurov Veli B.
doaj   +1 more source

Topics on the spectral properties of degenerate non-self-adjoint differential operators

Journal of Inequalities and Applications, 2016
Let ( P u ) ( t ) = − d d t ( ω 2 ( t ) q ( t ) d u ( t ) d t ) $( Pu ) ( t ) =- \frac{d}{dt} ( \omega^{2} ( t ) q ( t ) \frac{du ( t )}{dt} )$ be a degenerate non-self-adjoint operator defined on the space H ℓ = L 2 ( 0 , 1 ) ℓ $H_{\ell} = L^{2} (0,1)^{\
Ali Sameripour, Yousef Yadollahi
doaj   +1 more source

Commutable Matrix-Valued Functions and Operator-Valued Functions

Communications in Advanced Mathematical Sciences, 2020
A simple expression is established for an analytic commutable matrix-valued function. Then a characterization of two by two functional commutative matrices is proven.
Abdelaziz Maouche
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Limiting absorption principle and Strichartz estimates for Dirac operators in two and higher dimensions

, 2018
In this paper we consider Dirac operators in $\mathbb R^n$, $n\geq2$, with a potential $V$. Under mild decay and continuity assumptions on $V$ and some spectral assumptions on the operator, we prove a limiting absorption principle for the resolvent ...
Erdogan, Burak, Goldberg, Michael, Green, William R.   +2 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Entanglement Spectrum Resolved by Loop Symmetries

18+32 pages, 5+8 figures. Comments welcome!
Yagi, Haruki, Gong, Zongping
openaire   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Norm estimates of complex symmetric operators applied to quantum systems

, 2005
This paper communicates recent results in theory of complex symmetric operators and shows, through two non-trivial examples, their potential usefulness in the study of Schr\"odinger operators. In particular, we propose a formula for computing the norm of
Barbaroux J M, Brown G J N, Danciger J, Danciger J Garcia S R Putinar M, de Prunele E, Emil Prodan, Garcia S R, Glazman I M, Glazman I M, Hislop P D, Kohn W, Kronig R, McCurdy C W, Mihai Putinar, Reed M, Riss U V, Simon B, Stephan R Garcia   +17 more
core   +1 more source