Results 71 to 80 of about 516 (268)
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Linear and nonlinear abstract differential equations of high order
Open Mathematics, 2015 The nonlocal boundary value problems for linear and nonlinear degenerate abstract differential equations of arbitrary order are studied. The equations have the variable coefficients and small parameters in principal part.
Shakhmurov Veli B.
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Topics on the spectral properties of degenerate non-self-adjoint differential operators
Journal of Inequalities and Applications, 2016 Let ( P u ) ( t ) = − d d t ( ω 2 ( t ) q ( t ) d u ( t ) d t ) $( Pu ) ( t ) =- \frac{d}{dt} ( \omega^{2} ( t ) q ( t ) \frac{du ( t )}{dt} )$ be a degenerate non-self-adjoint operator defined on the space H ℓ = L 2 ( 0 , 1 ) ℓ $H_{\ell} = L^{2} (0,1)^{\
Ali Sameripour, Yousef Yadollahi
doaj +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
B-Weyl spectrum and poles of the resolvent
Journal of Mathematical Analysis and Applications, 2002 A bounded linear operator \(T\) on a Banach space \(X\) is called a \(B\)-Fredholm operator if for some integer \(n\), the range space \(R(T^n)\) is closed and \(T: R(T^n) \rightarrow R(T^n)\) is a Fredholm operator. When the index is \(0\), \(T\) is called a \(B\)-Weyl operator. In this case, the \(B\)-Weyl spectrum is defined by \(\sigma_{BW}(T) = \{
openaire +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Spectral properties of fractional differentiation operators
Electronic Journal of Differential Equations, 2018 We consider the fractional differentiation operators in a variety of senses. We show that the strong accretive property is the common property of fractional differentiation operators.
Maksim V. Kukushkin
doaj
The spectrum of α-resolvable block designs with block size 3
Discrete Mathematics, 1991 A balanced incomplete block design \(D(v,k,\lambda)\) is called \(\alpha\)- resolvable if its blocks can be partitioned into classes such that each point of the design lies in exactly \(\alpha\) blocks of each class. Necessary conditions for such a partitioning to exist include (i) \(bk=vr\); (ii) \(\lambda (v-1)=r(k-1)\); (iii) \(k\mid \alpha v\); (iv)
Jungnickel, Dieter +2 more
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