Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett +8 more
wiley +1 more source
Nonlinear Stability in a Free Boundary Model of Active Locomotion. [PDF]
Arch Ration Mech AnalBerlyand L, Safsten CA, Truskinovsky L.
europepmc +1 more source
Vestibular Patient Journey: Insights From Vestibular Disorders Association (VeDA) Registry
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Vestibular symptoms impose a high burden of disability. Understanding real‐world diagnostic and treatment pathways can identify care gaps and guide interventions. We aimed to characterize symptom profiles, diagnostic trends, provider involvement, and treatment patterns in vestibular disorders.
Ali Rafati +10 more
wiley +1 more source
Higher-order regularity for a structurally damped plate equation on rough domains. [PDF]
Math AnnDenk R, Roodenburg FB.
europepmc +1 more source
Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz +3 more
wiley +1 more source
Intertwining Operators Beyond the Stark Effect. [PDF]
Commun Math PhysFanelli L +4 more
europepmc +1 more source
Body-Ordered Approximations of Atomic Properties. [PDF]
Arch Ration Mech Anal, 2022 Thomas J, Chen H, Ortner C.
europepmc +1 more source
Ketogenic Diet as an Epigenetic Therapy in SETD1B‐Related Epilepsy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Histone lysine methyltransferases such as SETD1B regulate chromatin structure and gene transcription. Ketone bodies, including butyrate, act as histone deacetylase inhibitors. We report a 4‐year‐old boy with SETD1B‐related absence epilepsy, refractory to conventional medications, who achieved sustained > 90% seizure reduction on the Modified ...
Erica Tsang +10 more
wiley +1 more source
Normal typicality and dynamical typicality for a random block-band matrix model. [PDF]
Lett Math PhysErdős L, Henheik J, Vogel C.
europepmc +1 more source
Quantum adiabatic theorem for unbounded Hamiltonians with a cutoff and its application to superconducting circuits. [PDF]
Philos Trans A Math Phys Eng Sci, 2023 Mozgunov E, Lidar DA.
europepmc +1 more source