Results 101 to 110 of about 3,899,545 (360)
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
The Annals of Mathematical Statistics, 1961 This paper extends some results of Grenander [1] relating to discrete real stationary normal processes with absolutely continuous spectrum to the case in which the spectrum also contains a step function with a finite number of salt uses. It is shown by Grenander [1] that the periodogram is an asymptotically unbiased estimate of the spectral density $f(\
openaire +3 more sources
On the spectrum of silicon; with a note on the spectrum of fluorine [PDF]
Proceedings of the Royal Society of London. Series A, Containing Papers of a Mathematical and Physical Character, 1905 In a recent paper M. A. de Gramont questions the silicon origin of certain lines, viz.: λ 4089·1, λ 4096·9, and λ 4116·4, grouped together as Group IV by Sir Norman Lockyer who ascribes them to the element named. He says: “J’ajouterai que les lignes du groupe IV, qui indiqueraient, d’aprés Lockyer, une température excessive, ont toujours ...
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Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source
BJPsych OpenAims Referrals for adult autism assessment to the Cambridgeshire Lifespan Autism Spectrum Service (CLASS) have increased from 430 in 2019 to 887 in 2023, with demand exceeding capacity.
Janine Robinson +4 more
doaj +1 more source
Molecular Oncology, EarlyView.This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian +10 more
wiley +1 more source
Molecular Oncology, EarlyView.This real‐world study of ROS1+ NSCLC highlights fusion diversity, treatment outcomes with crizotinib and lorlatinib, and in vitro experiments with resistance mechanisms. G2032R drives strong resistance to ROS1‐targeted TKIs, especially lorlatinib. Fusion partner location does not affect overall survival to crizotinib or lorlatinib. Findings support the
Fenneke Zwierenga +8 more
wiley +1 more source
Gerontology and Geriatric MedicineThe study objective was to assess the feasibility of the Patient Benefit Assessment Scale (P-BAS), a digital tool designed to enable older outpatients (≥70 years) to elucidate at home their individual goals regarding their current medical issue.
Rozemarijn A.L. van Erp MSc +4 more
doaj +1 more source