Results 51 to 60 of about 6,098,114 (358)

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

FEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää, Ahmed B. Montaser, Henri Leinonen   +2 more
wiley   +1 more source

The effects of prehabilitation versus usual care to reduce postoperative complications in high-risk patients with colorectal cancer or dysplasia scheduled for elective colorectal resection: study protocol of a randomized controlled trial

BMC Gastroenterology, 2018
Background Of all older patients that opt for elective colorectal surgery, approximately one-third has one or more postoperative complications, particularly those patients with a low cardiorespiratory fitness (ventilatory anaerobic threshold (VAT)
Annefleur E. M. Berkel, Bart C. Bongers, Marie-Janne S. van Kamp, Hayke Kotte, Paul Weltevreden, Frans H. C. de Jongh, Michiel M. M. Eijsvogel, A. N. Machteld Wymenga, Marloes Bigirwamungu-Bargeman, Job van der Palen, Marc J. van Det, Nico L. U. van Meeteren, Joost M. Klaase   +12 more
doaj   +1 more source

Optimization of determination and application of complexly distributed loads on a double curvature cable-stayed covering

Vestnik MGSU, 2023
Introduction. In recent years, the development of programming affects more and more spheres, including the architectural and construction field.
V. A. Dagaev, G. M. Purvin, F. S. Shkoliar   +2 more
doaj   +1 more source

On the dispersion spectrum

Monatshefte f�r Mathematik, 1991
For irrational \(\alpha\) the dispersion constant \(D(\alpha)\) is defined as \(\lim\sup_{N\to \infty} Nd_ N\) with \(d_ N=\sup_{x\in[0,1]}\min_{1\leq n\leq N}| x-\{n\alpha\}|\) with \(\{ x\}\) being the fractional part of \(x\). It was shown by \textit{H. Niederreiter} [Topics in Classical Number Theory, Colloq. Math. Soc.
Schnitzer, F.J., Kopetzky, H.G.
openaire   +3 more sources

Spectrum of Spondyloarthritis

Indian Journal of Rheumatology, 2020
Spondyloarthritis (SpA) comprises a group of related diseases which share similar pathogenesis and clinical manifestations. Although the occurrence of SpA spectrum disorders has been known for some time, it was only in the latter half of the twentieth century that the concept of SpA was formally defined.
Pathak, Himanshu, Gaffney, Karl
openaire   +5 more sources

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Ventricular Septal Rupture in 2 Patients Presenting Late after Myocardial Infarction during the COVID-19 Pandemic

JACC: Case Reports, 2020
Ventricular septal rupture (VSR) following myocardial infarction is rare in the reperfusion era. The decrease in patients presenting with myocardial infarction during the coronavirus-2019 (COVID-19) pandemic could result in more frequent VSR. This report
Malav Parikh, MD, Meredith Busman, MD, Michael Dickinson, MD, David Wohns, MD, Ryan D. Madder, MD   +4 more
doaj   +1 more source

A Completely Endovascular Solution for Transcatheter Aortic Valve Implantation Embolisation and Inversion into the Aortic ArchWhat this paper adds

EJVES Vascular Forum, 2021
Introduction: Transcatheter aortic valve implantation (TAVI) has evolved into the preferred alternative to surgical valve replacement for severe aortic valve stenosis with high surgical risk.
Steven J.G. Leeuwerke, Theo P. Menting, Martin G. Stoel, Robert H. Geelkerken   +3 more
doaj   +1 more source

Goodbye flat lymphoma biology

FEBS Letters, EarlyView.
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria, Cèlia Dobaño‐López, Patricia Pérez‐Galán, Christine Bezombes   +3 more
wiley   +1 more source

The spectrum of independence [PDF]

Archive for Mathematical Logic, 2019
We study the set of possible sizes of maximal independent families to which we refer as spectrum of independence and denote Spec (mif). Here mif abbreviates maximal independent family. We show that:1.whenever κ 1< ⋯ < κ n are finitely many regular uncountable cardinals, it is consistent that {κi}i=1n⊆Spec(mif);2.whenever κ has uncountable ...
Vera Fischer, Saharon Shelah
openaire   +5 more sources