Results 51 to 60 of about 3,788,707 (345)

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

The effects of prehabilitation versus usual care to reduce postoperative complications in high-risk patients with colorectal cancer or dysplasia scheduled for elective colorectal resection: study protocol of a randomized controlled trial

BMC Gastroenterology, 2018
Background Of all older patients that opt for elective colorectal surgery, approximately one-third has one or more postoperative complications, particularly those patients with a low cardiorespiratory fitness (ventilatory anaerobic threshold (VAT)
Annefleur E. M. Berkel, Bart C. Bongers, Marie-Janne S. van Kamp, Hayke Kotte, Paul Weltevreden, Frans H. C. de Jongh, Michiel M. M. Eijsvogel, A. N. Machteld Wymenga, Marloes Bigirwamungu-Bargeman, Job van der Palen, Marc J. van Det, Nico L. U. van Meeteren, Joost M. Klaase   +12 more
doaj   +1 more source

Abstract Number ‐ 135: Surpass Evolve® Flow Diversion for Embolization of Unruptured Anterior Circulation Aneurysms: 6‐month Obliteration Rates

Stroke: Vascular and Interventional Neurology, 2023
Introduction The Surpass Evolve flow diverter (FD) is a 64‐wire cobalt‐chromium device with improved ease of deployment and conformability, compared to its predecessor. Data on procedural outcomes and aneurysm obliteration rate remain limited.
Leonard H Verhey, Andrea Sewell, Leah Lyons, Paul Mazaris, Justin Singer   +4 more
doaj   +1 more source

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

FEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg, Laura De Cnop, Bernd Nidetzky   +2 more
wiley   +1 more source

A patient with diffuse alveolar hemorrhage: A diagnostic dilemma

Respiratory Medicine Case Reports, 2020
Diffuse alveolar hemorrhage (DAH) is a usual presentation of pulmonary vasculitis. However, several rare conditions have a similar presentation. We present a 73-year-old man with DAH whose diagnosis only became conclusive near the end of his life.
Shahid A. Mohammed, Christina Heyboer, Meggen Walsh, Talawnda Bragg   +3 more
doaj  

Long‐Term Outcome of Consecutive Patients With Previous Coronary Bypass Surgery, Treated With Newer‐Generation Drug‐Eluting Stents

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
BackgroundPercutaneous coronary intervention (PCI) in patients with previous coronary artery bypass grafting (CABG) is associated with adverse clinical events.
Liefke C. van der Heijden, Marlies M. Kok, Paolo Zocca, Hanim Sen, Marije M. Löwik, Silvia Mariani, Frits H. A. F. de Man, Marc Hartmann, Martin G. Stoel, K. Gert van Houwelingen, J. (Hans) W. Louwerenburg, Gerard C. M. Linssen, Carine J. M. Doggen, Jan G. Grandjean, Clemens von Birgelen   +14 more
doaj   +1 more source

An Experiment on the Spectrum [PDF]

Nature, 1920
IN school and college courses little experimental work is done on the infra-red and ultra-violet parts of the spectrum. The student is, of course, told about these regions, and how they can be detected respectively by the heating and actinic properties of their rays. But he is not allowed to.
openaire   +3 more sources

Spectrum Trading for Efficient Spectrum Utilization [PDF]

EAI Endorsed Transactions on Wireless Spectrum, 2014
The conventional command and control based spectrum management has led to substantial underutilization of some spectrum bands while severely crowding others due to the uneven and dynamic needs that vary over time and at different locations. Spectrum trading has emerged as a promising management approach to substantially improve spectrum utilization and
Zhi Ding, Cong Xiong, Lu Lu, Daquan Feng, Geoffrey Ye Li, Helena Mitchell   +5 more
openaire   +2 more sources

P‐glycoprotein modulates the fluidity gradient of the plasma membrane of multidrug resistant CHO cells

FEBS Letters, EarlyView.
To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche, John R. Riordan, Burkhard Tümmler   +2 more
wiley   +1 more source

Identification, Evaluation, and Management of Children With Autism Spectrum Disorder

Pediatrics, 2019
Autism spectrum disorder (ASD) is a common neurodevelopmental disorder with reported prevalence in the United States of 1 in 59 children (approximately 1.7%).
S. Hyman, S. Levy, S. Myers
semanticscholar   +1 more source