Results 61 to 70 of about 6,098,114 (358)
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
Twins in Mesoamerica as a Symbol of Contrasting Duality [PDF]
, 2015 In cultures across the Mesoamerican subcontinent, there are examples in the archaeological and ethnographic record of myths concerned with twins and sibling pairs (Minneci, 1999).
Rideout, Benjamin
core +2 more sources
Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation
FEBS Letters, EarlyView.The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen +2 more
wiley +1 more source
Epilepsia Open, 2021 Drug‐resistant focal epilepsy with regional neocortical seizure onsets originating from the posterior quadrant can be particularly difficult to treat with resective surgery due to the overlap with eloquent cortex.
David Burdette +3 more
doaj +1 more source
Presenting Pompeii: Reconciling Relationships between Configuration and Conservation [PDF]
, 2013 Mark Twain’s idealized testimonial in his travelogue Innocents Abroad is not a revolutionary phenomenon. Pompeii has long been considered a city with breathtaking preservation, but the extent of preservation has been a recent source of controversy.
Sheldon, Karilyn
core +2 more sources
FEBS Letters, EarlyView.Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield +3 more
wiley +1 more source
Olympic Landscapes: A Global Event on a Local Landscape [PDF]
, 2012 Recently, cities around the globe have become involved in a competition for obtaining the title of the most “powerful” city in the world. Hosting mega-events, like the Olympics allow for these cities to restructure the entire floor plan of their ...
Silva, Krista
core +2 more sources
FEBS Letters, EarlyView.In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker +8 more
wiley +1 more source
The Value of the Dead: The Commodification of Corpses in Western Culture [PDF]
, 2018 Since the 19th century, the deceased human body and its parts have been increasingly dehumanized, objectified, and commodified in Western culture. Thus, in a relatively short period of time, the corpse became, and continues to be, a highly valuable ...
Wallace, Charles Z.
core +2 more sources
Development of visible light‐sensitive human neuropsin (OPN5) via single amino acid substitution
FEBS Letters, EarlyView.The present study determines a key amino acid residue, Lys91, for defining UV sensitivity of human OPN5. Heterologous action spectroscopy of the wild type and K91 mutants of OPN5 in HEK293T cells reveals that substitution of Lys91 with neutral (alanine) or acidic amino acids (glutamic or aspartic acids) causes substantial shifts in spectral sensitivity
Yusuke Sakai +2 more
wiley +1 more source