Results 151 to 160 of about 4,519,250 (293)

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Removal of cardiogenic oscillations during pressure support ventilation using sliding window singular spectrum analysis: proof-of-concept. [PDF]

Biomed Eng Online
Pagano PP, Ciaccio EJ.
europepmc   +1 more source

Characteristics of sarcopenia subjects in arterial pulse spectrum analysis. [PDF]

Front Public Health, 2022
Ou Young T, Wu LW, Hsiu H, Peng TC, Chen WL.   +4 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Genetic spectrum analysis of high-carrier-frequency monogenic disorders based on whole-exome sequencing in the Chinese general population. [PDF]

Hum Genomics
Hao N, Lü Y, Bian J, Yin K, Xiao R, Hu P, Peng Y, Huang M, Qiao F, Xiao R, Liu Y, You Y, Jiang Y.   +12 more
europepmc   +1 more source

Fast Image-Level MRI Harmonization via Spectrum Analysis. [PDF]

Mach Learn Med Imaging, 2022
Guan H, Liu S, Lin W, Yap PT, Liu M.
europepmc   +1 more source

Fluid and Neuroimaging Biomarkers in Microgliopathy Colony‐Stimulating Factor‐1 Receptor‐Related Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aims to identify both fluid and neuroimaging biomarkers for CSF1R‐RD that can inform the optimal timing of treatment administration to maximize therapeutic benefit, while also providing sensitive quantitative measurements to monitor disease progression.
Tomasz Chmiela, Madison Reeves, Karen Jansen‐West, Judith Dunmore, Yuping Song, Audrey Strongosky, Sunil Gandhi, Gilana Pikover, Matt Blurton‐Jones, Robert C. Spitale, Erik H. Middlebrooks, Leonard Petrucelli, Mercedes Prudencio, Zbigniew K. Wszolek   +13 more
wiley   +1 more source

Comprehensive serum glycopeptide spectrum analysis with machine learning for non-invasive early detection of gastrointestinal cancers. [PDF]

Comput Struct Biotechnol J
Hisamatsu Y, Tanabe K, Kudo K, Hasuda H, Kusumoto E, Uehara H, Yoshida R, Ota M, Sakaguchi Y, Hayashi C, Mikami M, Kusumoto T.   +11 more
europepmc   +1 more source

Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz, Josefine Eck, Joel S. Winston, Kate Baker   +3 more
wiley   +1 more source

The bidirectional modulation of acute aerobic exercise on cognitive performance and brain electrical activity in adolescents with smartphone addiction: an experimental study using EEG power spectrum analysis. [PDF]

Front Public Health
Che T, Long Y, Zhang S, Jiang X.
europepmc   +1 more source