Results 161 to 170 of about 27,933,437 (394)
The IFNγ‐CIITA‐MHC II axis modulates melanoma cell susceptibility to NK‐cell‐mediated cytotoxicity
Natural killer (NK) cells play a central role in anti‐melanoma immunity. However, melanoma cells adapt during co‐culture by upregulating CIITA and MHC II in response to interferon gamma (IFNγ), thereby evading NK‐cell lysis. Blocking IFNγ signaling or treatment with dimethyl fumarate/simvastatin counteracts this immune escape and maintains NK‐cell ...
Lena C. M. Krause+6 more
wiley +1 more source
Microplastics are a pervasive pollutant in aquatic ecosystems, raising critical environmental and public health concerns and driving the need for advanced detection technologies.
Xinwei Dong+8 more
doaj +1 more source
A contribution to quantitative and qualitative analysis with help of absorption spectrums [PDF]
J. Bačkovský
openalex +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia+9 more
wiley +1 more source
The CdO–CdCl2 reaction studied by thermal analysis and X-ray diffraction: X-ray diffractogram and infrared spectrum of CdCl2•2CdO [PDF]
P. Ramamurthy, E. A. Secco
openalex +1 more source
Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley +1 more source
The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity
We identified RNF219 as a CCR4‐NOT complex‐interacting E3 ubiquitin ligase that targets the CCR4‐NOT subunit CNOT6L for ubiquitination. RNF219 directly binds to the DUF3819 domain of CNOT1 through its putative α‐helix spanning amino acids 521–542. Our findings also suggest that antiproliferative activity of RNF219 is at least partially mediated by ...
Shou Soeda+9 more
wiley +1 more source
'Spectrum': Spectral Analysis in Python [PDF]
Thomas Cokelaer, Juergen Hasch
openaire +3 more sources
Periodic systems in time: double-well potential
Time analysis of oscillations of a particle between wells in the one-dimensional double-well potential with infinite high outside walls, based on wave packet use and energy spectrum analysis, is presented. For the double-well potential of the form $x^{2}+
Maydanyuk, Sergei P.
core +2 more sources