Results 91 to 100 of about 3,255,573 (367)

Functional analysis reveals that RBM10 mutations contribute to lung adenocarcinoma pathogenesis by deregulating splicing

Scientific Reports, 2017
RBM10 is an RNA splicing regulator that is frequently mutated in lung adenocarcinoma (LUAD) and has recently been proposed to be a cancer gene. How RBM10 mutations observed in LUAD affect its normal functions, however, remains largely unknown.
Jiawei Zhao, Yue Sun, Yin Huang, Fan Song, Zengshu Huang, Yufang Bao, J. Zuo, D. Saffen, Zhen Shao, Wen Liu, Yongbo Wang   +10 more
semanticscholar   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

The application bispherical coordinate in Schrödinger equation for Mobius square plus modified Yukawa potential using Nikiforov Uvarov Functional Analysis (NUFA) method

Journal of Physics: Theories and Applications, 2020
The application bispherical coordinates in Schrödinger equation for the Mobius square plus modified Yukawa potential have been obtained. The Schrödinger equation in bispherical coordinates for the separable Mobius square plus modified Yukawa potential ...
Briant Sabathino Harya Wibawa, A Suparmi, C Cari   +2 more
doaj   +1 more source

Voltage induced switching of an antiferromagnetically ordered topological Dirac semimetal

, 2018
An antiferromagnetic semimetal has been recently identified as a new member of topological semimetals that may host three-dimensional symmetry-protected Dirac fermions.
Gilbert, Matthew J., Kang, Kisung, Kim, Youngseok, Schleife, André   +3 more
core   +1 more source

Comparative meta-analyses of brain structural and functional abnormalities during cognitive control in attention-deficit/hyperactivity disorder and autism spectrum disorder

Psychological Medicine, 2020
Background People with attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) have abnormalities in frontal, temporal, parietal and striato-thalamic networks. It is unclear to what extent these abnormalities are distinctive or
S. Lukito, L. Norman, C. Carlisi, J. Raduà, H. Hart, E. Simonoff, K. Rubia   +6 more
semanticscholar   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

A Look Into the Power of fNIRS Signals by Using the Welch Power Spectral Estimate for Deception Detection

Frontiers in Human Neuroscience, 2021
Neuroimaging technologies have improved our understanding of deception and also exhibit their potential in revealing the origins of its neural mechanism. In this study, a quantitative power analysis method that uses the Welch power spectrum estimation of
Jiang Zhang, Jingyue Zhang, Houhua Ren, Qihong Liu, Zhengcong Du, Lan Wu, Liyang Sai, Liyang Sai, Zhen Yuan, Site Mo, Xiaohong Lin   +10 more
doaj   +1 more source

Analysis of Brain Imaging Data for the Detection of Early Age Autism Spectrum Disorder Using Transfer Learning Approaches for Internet of Things

IEEE transactions on consumer electronics
In recent years, advanced magnetic resonance imaging (MRI) methods including as functional magnetic resonance imaging (fMRI) and structural magnetic resonance imaging (sMRI) have indicated an increase in the prevalence of neuropsychiatric disorders. Data
Adnan Ashraf, Qingjie Zhao, W. Bangyal, Muddesar Iqbal   +3 more
semanticscholar   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Demand-aware traffic cooperation for self-organizing cognitive small-cell networks

International Journal of Distributed Sensor Networks, 2019
This article investigates the problem of efficient spectrum access for traffic demands of self-organizing cognitive small-cell networks, using the coalitional game approach.
Changhua Yao, Lei Zhu, Yongxing Jia, Lei Wang   +3 more
doaj   +1 more source