Results 91 to 100 of about 3,144,666 (363)

Atypical miRNA expression in temporal cortex associated with dysregulation of immune, cell cycle, and other pathways in autism spectrum disorders. [PDF]

, 2015
BackgroundAutism spectrum disorders (ASDs) likely involve dysregulation of multiple genes related to brain function and development. Abnormalities in individual regulatory small non-coding RNA (sncRNA), including microRNA (miRNA), could have profound ...
Ander, Bradley P, Barger, Nicole, Schumann, Cynthia M, Sharp, Frank R, Stamova, Boryana   +4 more
core   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Topologically convergent and divergent large scale complex networks among Alzheimer's disease spectrum patients: A systematic review

Heliyon, 2023
Alzheimer's disease (AD) is associated with disruption at the level of a large-scale complex network. To explore the underlying mechanisms in the progression of AD, graph theory was used to quantitatively analyze the topological properties of structural ...
Zhiyuan Yang, Ya Chen, Xinle Hou, Yun Xu, Feng Bai   +4 more
doaj   +1 more source

A Model of Emotion as Patterned Metacontrol [PDF]

, 2011
Adaptive systems use feedback as a key strategy to cope with uncertainty and change in their environments. The information fed back from the sensorimotor loop into the control architecture can be used to change different elements of the controller at ...
Sanz Bravo, Ricardo, Sánchez Escribano, María Guadalupe   +1 more
core   +1 more source

Evidence of a Curved Synchrotron Spectrum in the Supernova Remnant SN 1006

, 2008
A joint spectral analysis of some Chandra ACIS X-ray data and Molonglo Observatory Synthesis Telescope radio data was performed for 13 small regions along the bright northeastern rim of the supernova remnant SN 1006.
Aharonian F. A., Bamba A., Bell A. R., Drury L., G. E. Allen, J. C. Houck, Lagage P.-O., Milne D. K., Milne D. K., S. J. Sturner, Stephenson F. R., Webb G. M.   +11 more
core   +1 more source

Similar Microbial Communities Found on Two Distant Seafloor Basalts. [PDF]

, 2015
The oceanic crust forms two thirds of the Earth's surface and hosts a large phylogenetic and functional diversity of microorganisms. While advances have been made in the sedimentary realm, our understanding of the igneous rock portion as a microbial ...
Chong, Lauren S, Edwards, Katrina J, Heidelberg, John F, Singer, Esther   +3 more
core   +3 more sources

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

FEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield, Torsten Kleffmann, David J. Saul, Sigurd M. Wilbanks   +3 more
wiley   +1 more source

Demand-aware traffic cooperation for self-organizing cognitive small-cell networks

International Journal of Distributed Sensor Networks, 2019
This article investigates the problem of efficient spectrum access for traffic demands of self-organizing cognitive small-cell networks, using the coalitional game approach.
Changhua Yao, Lei Zhu, Yongxing Jia, Lei Wang   +3 more
doaj   +1 more source

Physicochemical Characterization and Functional Analysis of the Polysaccharide from the Edible Microalga Nostoc sphaeroides

Molecules, 2018
Nostoc colonies have been used as food and medicine for centuries, and their main supporting matrix is polysaccharides, which help Nostoc cells resist various environmental stresses including oxidative stress.
Haifeng Li, Linnan Su, Sheng Chen, Libin Zhao, Hongyu Wang, Fei Ding, Hong Chen, Ruona Shi, Yulan Wang, Zebo Huang   +9 more
semanticscholar   +1 more source

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source