Results 71 to 80 of about 1,879,007 (290)

Comparative analysis of group information-guided independent component analysis and independent vector analysis for assessing brain functional network characteristics in autism spectrum disorder

Frontiers in Neuroscience, 2023
IntroductionGroup information-guided independent component analysis (GIG-ICA) and independent vector analysis (IVA) are two methods that improve estimation of subject-specific independent components in neuroimaging studies.
Junlin Jing, Benjamin Klugah-Brown, Shiyu Xia, Min Sheng, Bharat B. Biswal, Bharat B. Biswal   +5 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Altered Functional Connectivity in Children With Low-Function Autism Spectrum Disorders

Frontiers in Neuroscience, 2019
Neuroimaging studies have shown that autism spectrum disorders (ASDs) may be associated with abnormalities in brain structures and functions at rest as well as during cognitive tasks.
Shoujun Xu, Shoujun Xu, Shoujun Xu, Meng Li, Chunlan Yang, Xiangling Fang, Miaoting Ye, Lei Wei, Jian Liu, Baojuan Li, Yungen Gan, Binrang Yang, Wenxian Huang, Peng Li, Xianlei Meng, Yunfan Wu, Yunfan Wu, Guihua Jiang, Guihua Jiang   +18 more
doaj   +1 more source

The Functional Pitch of an Organ: Quantification of Tissue Texture with Photoacoustic Spectrum Analysis

Radiology, 2014
To investigate the use of photoacoustic (PA) spectrum analysis (PASA) to identify microstructural changes corresponding to fat accumulation in mouse livers ex vivo and in situ.The laboratory animal protocol for this work was approved by the university committee on use and care of animals.
Guan, Xu, Zhuo-Xian, Meng, Jiandie D, Lin, Jie, Yuan, Paul L, Carson, Bhuwan, Joshi, Xueding, Wang   +6 more
openaire   +3 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Thickness dependent structural and electronic properties of CuO adsorbed on SrTiO3(100): a hybrid density functional theory study

, 2010
We discuss the structural and electronic properties of tetragonal CuO grown on SrTiO3(100) by means of hybrid density functional theory. Our analysis explains the anomalously large Cu-O vertical distance observed in the experiments (~2.7 A) in terms of a
Chen, Xing-Qiu, Franchini, C., Podloucky, R.   +2 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Vitamin D Deficiency During Pregnancy and Autism Spectrum Disorders Development

Frontiers in Psychiatry, 2020
Autism spectrum disorder is a neurodevelopmental disorder characterized by reduced social interactions, impaired communications, and stereotypic and repetitive behavior with different degrees of severity.
Nicola Principi, Susanna Esposito
doaj   +1 more source

Stability analysis of multiple nonequilibrium fixed points in self-consistent electron transport calculations

, 2011
We present a method to perform stability analysis of nonequilibrium fixed points appearing in self-consistent electron transport calculations. The nonequilibrium fixed points are given by the self-consistent solution of stationary, nonlinear kinetic ...
Dzhioev, Alan A., Kosov, D. S.
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source