Results 51 to 60 of about 1,879,007 (290)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Characterizing and Predicting Autism Spectrum Disorder by Performing Resting-State Functional Network Community Pattern Analysis

Frontiers in Human Neuroscience, 2019
Growing evidence indicates that autism spectrum disorder (ASD) is a neuropsychological disconnection syndrome that can be analyzed using various complex network metrics used as pathology biomarkers.
Yuqing Song, Thomas Martial Epalle, Hu Lu   +2 more
doaj   +1 more source

Scaling properties of the redshift power spectrum: theoretical models [PDF]

, 2000
We report the results of an analysis of the redshift power spectrum $P^S(k,\mu)$ in three typical Cold Dark Matter (CDM) cosmological models, where $\mu$ is the cosine of the angle between the wave vector and the line-of-sight.
Ballinger W. E., Cole S., Cole S., Efstathiou G., Fisher K. B., Fisher K. B., G. Borner, Jing Y. P., Kaiser N., Mo H. J., Mo H. J., Mo H. J., Peacock J. A., Sheth R. K., Suto Y., Taylor A. N., Y. P. Jing   +16 more
core   +2 more sources

Health‐Related Quality of Life and Symptom Severity Among Patients With PIK3CA‐Related Overgrowth Spectrum: A Mixed‐Methods Study to Understand Real‐World Experience With Alpelisib Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background PIK3CA‐related overgrowth spectrum (PROS) includes several rare overgrowth disorders resulting from somatic gain‐of‐function mutations in PIK3CA. Despite treatment advances, including the recent approval of alpelisib for PROS in the United States, literature detailing the patient experience with PROS is limited.
Vamsi Bollu, Kaitlin LaGasse, Cory D. Saucier, Kimberly Raymond, Miranda Lauher‐Charest, Lauren Crowder, Beilei Cai, Mary Lisha Paul, Denise Adams   +8 more
wiley   +1 more source

Reduced task-dependent modulation of functional network architecture for positive versus negative affective touch processing in autism spectrum disorders

NeuroImage, 2020
Individuals with autism spectrum disorders (ASD) experience impairments in social communication and interaction, and often show difficulties with receiving and offering touch.
Haemy Lee Masson, Hans Op de Beeck, Bart Boets   +2 more
doaj   +1 more source

Multiplexed functional genomic analysis of 5’ untranslated region mutations across the spectrum of prostate cancer

Nature Communications, 2021
Mutations in 5’ untranslated regions (UTRs) have a functional role in gene expression in cancer. Here, the authors develop a sequencing-based high throughput functional assay named PLUMAGE and show the effects of these mutations on gene expression and ...
Yiting Lim, Sonali Arora, Samantha L. Schuster, Lukas Corey, Matthew Fitzgibbon, Cynthia L. Wladyka, Xiaoying Wu, Ilsa M. Coleman, Jeffrey J. Delrow, Eva Corey, Lawrence D. True, Peter S. Nelson, Gavin Ha, Andrew C. Hsieh   +13 more
doaj   +1 more source

Therapeutic Apheresis for Intravenous Methylprednisolone‐Refractory Neuromyelitis Optica Spectrum Disorder: Clinical and Radiological Outcomes in a Single‐Center Case Series

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing autoimmune disease of the central nervous system. High‐dose intravenous methylprednisolone (IVMP) is the standard first‐line therapy for acute attacks, although some patients remain refractory.
Wataru Horiguchi, Daisuke Katagiri, Takeyuki Watadani, Shunichi Matsuda, Hiroshi Kaneko, Noritoshi Arai   +5 more
wiley   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Unified Functional Spectrum Analysis: A Framework for Understanding Nonverbal Multimodal Multifunctional Interactions in Multiparty Conversations

IEEE Access
An analytic framework called unified functional spectrum analysis (U-FSA) to reveal the multimodal multifunctional interplay that emerges and comprises interpersonal interactions in multiparty conversations is proposed.
Momoka Tajima, Issa Tamura, Ayaka Sasaki, Kazuhiro Otsuka   +3 more
doaj   +1 more source

A novel FAM83H variant causes familial amelogenesis imperfecta with incomplete penetrance

Molecular Genetics & Genomic Medicine, 2022
Background Amelogenesis imperfecta (AI) is known to be a monogenic genetic disease caused by a variety of genes demonstrating a wide spectrum of penetrance.
Rui‐Qi Bai, Wen‐Bin He, Qian Peng, Su‐Hui Shen, Qian‐Qian Yu, Juan Du, Yue‐Qiu Tan, Yue‐Hong Wang, Bin‐Jie Liu   +8 more
doaj   +1 more source