Results 41 to 50 of about 1,601,744 (327)

Steroidal MRA Across the Spectrum of Renal Function: A Pooled Analysis of RCTs. [PDF]

open access: yesJACC. Heart failure, 2022
Mineralocorticoid receptor antagonists (MRAs) are underused in patients with kidney dysfunction, and their efficacy among patients with chronic kidney disease (CKD) is uncertain.The goal of this study was to analyze the efficacy and safety of steroidal MRAs across the spectrum of estimated glomerular filtration rates (eGFRs) in randomized controlled ...
Ferreira, João Pedro   +7 more
openaire   +1 more source

Altered Functional Connectivity in Children With Low-Function Autism Spectrum Disorders

open access: yesFrontiers in Neuroscience, 2019
Neuroimaging studies have shown that autism spectrum disorders (ASDs) may be associated with abnormalities in brain structures and functions at rest as well as during cognitive tasks.
Shoujun Xu   +18 more
doaj   +1 more source

Disrupted Dynamic Functional Connectivity in Distinguishing Subjective Cognitive Decline and Amnestic Mild Cognitive Impairment Based on the Triple-Network Model

open access: yesFrontiers in Aging Neuroscience, 2021
Background: Subjective cognitive decline and amnestic mild cognitive impairment (aMCI) were widely thought to be preclinical AD spectrum disorders, characterized by aberrant functional connectivity (FC) within the triple networks of the default mode ...
Chen Xue   +9 more
doaj   +1 more source

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

open access: yesFEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi   +3 more
wiley   +1 more source

Detailed molecular structure (XRD), conformational search, spectroscopic characterization (IR, Raman, UV, fluorescence), quantum mechanical properties and bioactivity prediction of a pyrrole analogue

open access: yesHeliyon, 2020
Pyrroles are an exciting class of organic compounds with immense medicinal activities. This manuscript presents the structural and quantum mechanical studies of 1-(2-aminophenyl) pyrrole using X-Ray diffraction and various spectroscopic methods like ...
Katta Eswar Srikanth   +6 more
doaj  

Vitamin D Deficiency During Pregnancy and Autism Spectrum Disorders Development

open access: yesFrontiers in Psychiatry, 2020
Autism spectrum disorder is a neurodevelopmental disorder characterized by reduced social interactions, impaired communications, and stereotypic and repetitive behavior with different degrees of severity.
Nicola Principi, Susanna Esposito
doaj   +1 more source

ANKRD54 preferentially selects Bruton's Tyrosine Kinase (BTK) from a Human Src-Homology 3 (SH3) domain library. [PDF]

open access: yesPLoS ONE, 2017
Bruton's Tyrosine Kinase (BTK) is a cytoplasmic protein tyrosine kinase with a fundamental role in B-lymphocyte development and activation. The nucleocytoplasmic shuttling of BTK is specifically modulated by the Ankyrin Repeat Domain 54 (ANKRD54) protein
Manuela O Gustafsson   +8 more
doaj   +1 more source

Comparative analysis of group information-guided independent component analysis and independent vector analysis for assessing brain functional network characteristics in autism spectrum disorder

open access: yesFrontiers in Neuroscience, 2023
IntroductionGroup information-guided independent component analysis (GIG-ICA) and independent vector analysis (IVA) are two methods that improve estimation of subject-specific independent components in neuroimaging studies.
Junlin Jing   +5 more
doaj   +1 more source

Spectrum and Fine Spectrum of Band Matrices Generated by Oscillatory Sequences [PDF]

open access: yesarXiv, 2023
In this paper, a new class of band matrices is considered where the entries of each non-zero band form a sequence with two limit points. The compact perturbation technique is used to study the spectrum over the $\ell_{p}, (1
arxiv  

RAId_aPS: MS/MS Analysis with Multiple Scoring Functions and Spectrum-Specific Statistics

open access: yesPLoS ONE, 2010
Statistically meaningful comparison/combination of peptide identification results from various search methods is impeded by the lack of a universal statistical standard. Providing an E-value calibration protocol, we demonstrated earlier the feasibility of translating either the score or heuristic E-value reported by any method into the textbook-defined
Aleksey Y. Ogurtsov   +2 more
openaire   +6 more sources

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