Results 51 to 60 of about 722,096 (265)
Vitamin D Deficiency During Pregnancy and Autism Spectrum Disorders Development
Frontiers in Psychiatry, 2020 Autism spectrum disorder is a neurodevelopmental disorder characterized by reduced social interactions, impaired communications, and stereotypic and repetitive behavior with different degrees of severity.
Nicola Principi, Susanna Esposito
doaj +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
ANKRD54 preferentially selects Bruton's Tyrosine Kinase (BTK) from a Human Src-Homology 3 (SH3) domain library. [PDF]
PLoS ONE, 2017 Bruton's Tyrosine Kinase (BTK) is a cytoplasmic protein tyrosine kinase with a fundamental role in B-lymphocyte development and activation. The nucleocytoplasmic shuttling of BTK is specifically modulated by the Ankyrin Repeat Domain 54 (ANKRD54) protein
Manuela O Gustafsson +8 more
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Frontiers in PediatricsBackgroundMotor coordination impairment among children with autism spectrum disorder (ASD) has recently gained increasing attention. However, the relationship between functional connectivity (FC) alterations and motor coordination impairment among ASD ...
Muqing Cao, Chengkai Jin, Jin Jing
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Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Frontiers in Neurology, 2018 Background: There is accumulating evidence showing that patients with autism spectrum disorder (ASD) have obvious changes in resting-state functional brain activity. So far, there have been no meta-analyses of the resting-state brain activity alterations
Wenhui Wang +9 more
doaj +1 more source
Journal of Physics: Theories and Applications, 2020 The application bispherical coordinates in Schrödinger equation for the Mobius square plus modified Yukawa potential have been obtained. The Schrödinger equation in bispherical coordinates for the separable Mobius square plus modified Yukawa potential ...
Briant Sabathino Harya Wibawa +2 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Irony Comprehension in High-Function Autism Spectrum Disorders: A Meta-Analysis
Communication Sciences & Disorders, 2023 Objectives: Irony is a type of figurative language that conveys the opposite meaning of what is said, and it is known to cause difficulty for those with autism spectrum disorder because the expression of spoken language and the non-verbal context are inconsistent.
Younjung Choi +2 more
openaire +1 more source