Results 51 to 60 of about 1,572,195 (325)

Vitamin D Deficiency During Pregnancy and Autism Spectrum Disorders Development

Frontiers in Psychiatry, 2020
Autism spectrum disorder is a neurodevelopmental disorder characterized by reduced social interactions, impaired communications, and stereotypic and repetitive behavior with different degrees of severity.
Nicola Principi, Susanna Esposito
doaj   +1 more source

ANKRD54 preferentially selects Bruton's Tyrosine Kinase (BTK) from a Human Src-Homology 3 (SH3) domain library. [PDF]

PLoS ONE, 2017
Bruton's Tyrosine Kinase (BTK) is a cytoplasmic protein tyrosine kinase with a fundamental role in B-lymphocyte development and activation. The nucleocytoplasmic shuttling of BTK is specifically modulated by the Ankyrin Repeat Domain 54 (ANKRD54) protein
Manuela O Gustafsson, Dara K Mohammad, Erkko Ylösmäki, Hyunseok Choi, Subhash Shrestha, Qing Wang, Beston F Nore, Kalle Saksela, C I Edvard Smith   +8 more
doaj   +1 more source

Multimodal MRI analysis of basal forebrain structure and function across the Alzheimer’s disease spectrum

NeuroImage: Clinical, 2020
Dysfunction of the cholinergic basal forebrain (cBF) is associated with cognitive decline in Alzheimer's disease (AD). Multimodal MRI allows for the investigation of cBF changes in-vivo. In this study we assessed alterations in cBF functional connectivity (FC), mean diffusivity (MD), and volume across the spectrum of AD.
Herdick, Meret, Dyrba, Martin, Fritz, Hans-Christian J., Altenstein, Slawek, Ballarini, Tommaso, Brosseron, Frederic, Buerger, Katharina, Cetindag, Arda Can, Dechent, Peter, Dobisch, Laura, Duezel, Emrah, Ertl-Wagner, Birgit, Fliessbach, Klaus, Freiesleben, Silka Dawn, Frommann, Ingo, Glanz, Wenzel, Haynes, John-Dylan, Heneka, Michael T., Janowitz, Daniel, Kilimann, Ingo, Laske, Christoph, Metzger, Coraline D., Munk, Matthias H., Peters, Oliver, Priller, Josef, Roy, Nina, Scheffler, Klaus, Schneider, Anja, Spottke, Annika, Spruth, Eike Jakob, Tscheuschler, Maike, Vukovich, Ruth, Wiltfang, Jens, Jessen, Frank, Teipel, Stefan J., Grothe, Michel J.   +35 more
openaire   +10 more sources

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

RAId_aPS: MS/MS Analysis with Multiple Scoring Functions and Spectrum-Specific Statistics

PLoS ONE, 2010
Statistically meaningful comparison/combination of peptide identification results from various search methods is impeded by the lack of a universal statistical standard. Providing an E-value calibration protocol, we demonstrated earlier the feasibility of translating either the score or heuristic E-value reported by any method into the textbook-defined
Aleksey Y. Ogurtsov, Gelio Alves, Yi-Kuo Yu   +2 more
openaire   +6 more sources

Functional variation among LPMOs revealed by the inhibitory effects of cyanide and buffer ions

FEBS Letters, EarlyView.
This study addresses the inhibition of lytic polysaccharide monooxygenases (LPMOs) by cyanide and explains how and why the magnitude of observed inhibitory effects depends on the way LPMO reactions are setup and on the type of LPMO. Enzymes known as lytic polysaccharide monooxygenases (LPMOs) are mono‐copper polysaccharide‐degrading peroxygenases that ...
Ole Golten, Lorenz Schwaiger, Zarah Forsberg, Kelsi R. Hall, Anton A. Stepnov, Tom Z. Emrich‐Mills, Iván Ayuso‐Fernández, Morten Sørlie, Roland Ludwig, Åsmund Kjendseth Røhr, Vincent G. H. Eijsink   +10 more
wiley   +1 more source

Association between composite scores of domain-specific cognitive functions and regional patterns of atrophy and functional connectivity in the Alzheimer’s disease spectrum

NeuroImage: Clinical, 2021
Background: Cognitive decline has been found to be associated with gray matter atrophy and disruption of functional neural networks in Alzheimer’s disease (AD) in structural and functional imaging (fMRI) studies.
Chimezie O. Amaefule, Martin Dyrba, Steffen Wolfsgruber, Alexandra Polcher, Anja Schneider, Klaus Fliessbach, Annika Spottke, Dix Meiberth, Lukas Preis, Oliver Peters, Enise I. Incesoy, Eike J. Spruth, Josef Priller, Slawek Altenstein, Claudia Bartels, Jens Wiltfang, Daniel Janowitz, Katharina Bürger, Christoph Laske, Matthias Munk, Janna Rudolph, Wenzel Glanz, Laura Dobisch, John D. Haynes, Peter Dechent, Birgit Ertl-Wagner, Klaus Scheffler, Ingo Kilimann, Emrah Düzel, Coraline D. Metzger, Michael Wagner, Frank Jessen, Stefan J. Teipel   +32 more
doaj  

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

The application bispherical coordinate in Schrödinger equation for Mobius square plus modified Yukawa potential using Nikiforov Uvarov Functional Analysis (NUFA) method

Journal of Physics: Theories and Applications, 2020
The application bispherical coordinates in Schrödinger equation for the Mobius square plus modified Yukawa potential have been obtained. The Schrödinger equation in bispherical coordinates for the separable Mobius square plus modified Yukawa potential ...
Briant Sabathino Harya Wibawa, A Suparmi, C Cari   +2 more
doaj   +1 more source