Results 71 to 80 of about 1,601,744 (327)
Molecular Oncology, EarlyView.This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini +10 more
wiley +1 more source
Spectra of some composition operators and associated weighted composition operators [PDF]
arXiv, 2009 We characterize the spectrum and essential spectrum of "essentially linear fractional" composition operators acting on the Hardy space H-two of the open unit disc U. When the symbols of these composition operators have Denjoy-Wolff point on the unit circle, the spectrum and essential spectrum coincide.
arxiv
Shift invariant space and FMRA on Vilenkin group [PDF]
arXiv, 2022 We construct the spectrum for a shift invariant space on Vilenkin group. We prove the results related to spectrum and Frame multiresolution analysis for Cantor dyadic group and Vilenkin group.
arxiv
Molecular Oncology, EarlyView.TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair +17 more
wiley +1 more source
Ecology and EvolutionFunctional traits reflect plants' adaptability to their environment, and environmental gradients influence their distribution. But few studies have investigated the link between these traits and species substitution patterns or the relevant ecological ...
Jun Yang +5 more
doaj +1 more source
A function with support of finite measure and "small" spectrum [PDF]
arXiv, 2017 We construct a function on the real line supported on a set of finite measure whose spectrum has density zero.
arxiv
Molecular Oncology, EarlyView.Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser +11 more
wiley +1 more source
Spectrum and fine spectrum of generalised lower triangular triple band matrices over the sequence space $l_p$ [PDF]
arXiv, 2018 The spectrum of triangular band matrices defined on the sequence spaces where the entries of each band is a constant or convergent sequence is well studied. In this article, the spectrum and fine spectrum of a new generalised difference operator defined by a lower triangular triple band matrix on the sequence space $l_p (1 \leq p < \infty)$ are ...
arxiv
Molecular Oncology, EarlyView.We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau +11 more
wiley +1 more source
IEEE Transactions on Neural Systems and Rehabilitation EngineeringDopaminergic treatment has proved effective to Parkinson’s disease (PD), but the conventional treatment assessment is human-administered and prone to intra- and inter-assessor variability. In this paper, we propose a knowledge-driven framework and
Jiewei Lu +10 more
doaj +1 more source