Results 21 to 30 of about 202,826 (204)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Database-Assisted Spectrum Sharing in Satellite Communications: A Survey

IEEE Access, 2017
This survey paper discusses the feasibility of sharing the spectrum between satellite telecommunication networks and terrestrial and other satellite networks on the basis of a comprehensive study carried out as part of the European Space Agency's ...
Marko Hoyhtya, Aarne Mammela, Xianfu Chen, Ari Hulkkonen, Janne Janhunen, Jean-Christophe Dunat, Jonathan Gardey   +6 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Study on optimization strategy for hybrid underlay/overlay spectrum sharing based on queuing model

Tongxin xuebao, 2017
In order to improve the licensed spectrum utilization in cognitive radio networks,and provide higher experience quality to system users,the optimizing strategies of the hybrid underlay/overlay spectrum sharing mode was studied.For secondary users,a ...
Jian-ping LIU, Shun-fu JIN, Bao-shuai WANG   +2 more
doaj   +2 more sources

A Novel Dynamic Spectrum-Sharing Method for GEO and LEO Satellite Networks

IEEE Access, 2020
In this article, we investigate the spectrum-sharing for a space information network comprised of a geostationary orbit (GEO) satellite and a pair of low earth orbit (LEO) satellites, where one spectrum-sensing LEO (SLEO) is used to sense the status of ...
Yunfeng Wang, Xiaojin Ding, Gengxin Zhang   +2 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Dual-target WOA spectrum sharing algorithm based on Stackelberg game

Tongxin xuebao, 2020
In order to solve the complex spectrum allocation problem,a dual-target whale optimization algorithm (WOA) with strong parallel computing capabilities was introduced,and a Stackelberg game model was proposed that could effectively reflect the actual ...
Li ZHANG, Tian LIAO, Yejun HE
doaj   +2 more sources

Scheduling Heterogeneous Wireless Systems for Efficient Spectrum Access

EURASIP Journal on Wireless Communications and Networking, 2010
The spectrum scarcity problem emerged in recent years, due to unbalanced utilization of RF (radio frequency) bands in the current state of wireless spectrum allocations.
Liao Shenghui, Bao Lichun
doaj   +2 more sources

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source