Results 121 to 130 of about 12,569,645 (317)

Pre-letting of office developments : a guide for occupiers [PDF]

open access: yes, 2007
‘Pre-letting’ is an agreement between a potential tenant and a developer to lease a building whose construction has not yet started. Benefits typically flow to both parties from a pre-letting, however, opportunities to pre-let are limited by place, time,
Cooke, Howard, Fisher, Peter, Morley, S.
core  

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

The Illegal Town Plan: Anecdotal Speculation for Coastal Futures

open access: yesTemes de Disseny, 2020
The Illegal Town Plan aims to understand and develop community- based futures for economic and social development. This case study describes and analyses an ongoing practice-based research project that began in 2015.
Matt Ward, Jimmy Loizeau
doaj  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Building a New World in the Shell of the Old: Co-Designing Post-Capitalist Visions

open access: yesSocieties
Designers working towards social change have often focused on designing discrete solutions to social problems, rather than working within the long-term world-making practices of movements.
Alix Gerber
doaj   +1 more source

MOON: MapReduce On Opportunistic eNvironments [PDF]

open access: yes, 2009
—MapReduce offers a flexible programming model for processing and generating large data sets on dedicated resources, where only a small fraction of such resources are every unavailable at any given time.
Archuleta, Jeremy   +5 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

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