Results 151 to 160 of about 13,837,759 (376)
Transistórias: how a critical and speculative perspective contributes to rethink sustainability education in product design [PDF]
, 2021 Inês Veiga
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FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Electric feels: The role of visual methods in energy ‘futuring’
Geo: Geography and Environment‘How would you feel about computers telling you how to save energy?’—was just one of many questions we asked our participants engaging with four artworks commissioned for the 'Electric Feels' project.
Joe Bourne +5 more
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Imagining Alternative Futures: ethnography through critical and speculative design workshops.
, 2021 Camila Monteiro Pereira
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Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Student Perspectives on Learning and Teaching Data Ethics Through Speculative Game Design [PDF]
Nisha Devasia +4 more
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FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
TATuP – Zeitschrift für Technikfolgenabschätzung in Theorie und PraxisBased on a case study in Franconia, Germany, where beetle infestation of spruce trees is high, we present an interdisciplinary approach from materials science, cultural theory, and computational design to develop architectures for syntopic living.
Pelin Asa +3 more
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Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source