Results 81 to 90 of about 9,382,675 (275)
The Illegal Town Plan: Anecdotal Speculation for Coastal Futures
Temes de Disseny, 2020 The Illegal Town Plan aims to understand and develop community- based futures for economic and social development. This case study describes and analyses an ongoing practice-based research project that began in 2015.
Matt Ward, Jimmy Loizeau
doaj
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Building a New World in the Shell of the Old: Co-Designing Post-Capitalist Visions
SocietiesDesigners working towards social change have often focused on designing discrete solutions to social problems, rather than working within the long-term world-making practices of movements.
Alix Gerber
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Speculative Fabulation to Reclaim the Verbal Dimension of Co-design [PDF]
, 2023 Man has always been a narrating animal. In 2009, the literary critic Brian Boyd offered the first comprehensive account of the evolutionary origins of storytelling.
Padula, Cecilia, Barbero, Silvia
core
Discourse, speculation and multidisciplinarity: Designing urban futures
Nordic Design Research Conference, 2015 This paper presents a design case study, a summer school that brought together a multi-disciplinary group of early- career professionals to explore ideas relating to new technologies in an urban context. The organisers of this school took an explicitly design-informed approach to the event, specifically a ‘critical design’ approach.
Helgason, Ingi +3 more
openaire +2 more sources
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Speculative Designs: Towards a Social Music.
, 2023 This paper introduces a collaborative research project in which the authors explored the possibilities of music making using social media. We aimed for this music to reflect the various genres born of social media, for example the selfie, the tweet, the emoticon.
Ouzounian, G, Haworth, C, Bennett, P
openaire +2 more sources