Results 81 to 90 of about 131,132 (344)
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
The Need for Empirically-Led Synthetic Philosophy [PDF]
, 2013 The problem of unifying knowledge represents the frontier between science and philosophy. Science approaches the problem analytically bottom-up whereas, prior to the end of the nineteenth century, philosophy approached the problem synthetically top-down.
Scoular, Spencer
core +1 more source
Putting speculation and new materialisms in dialogue
Palgrave Communications, 2019 AbstractOver the past decade, numerous disciplines have taken on speculation as a method for research, a tool for thought, or a topic of study. In so doing, sociology, politics, design, geography and other disciplines have all helped to readdress the nature and potential of speculation, as a way of thinking, but also as a way to bridge the gap between ...
openaire +2 more sources
FEBS Letters, EarlyView.At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom +3 more
wiley +1 more source
Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source
Deriving the Spiritual from the Material: A Speculatively Realist Perspective
ReligionsThe existence of the spiritual can be deduced from knowledge of the material. There is an inherent affinity between speculation and spirituality: an embrace of gaps in knowledge.
Ian McLaughlin
doaj +1 more source
Feminist Geopolitics: Material States [PDF]
, 2017 No abstract ...
Clark, Nigel +4 more
core +1 more source
Molecular Oncology, EarlyView.In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern +7 more
wiley +1 more source
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source