Results 81 to 90 of about 31,090 (297)

Deriving the Spiritual from the Material: A Speculatively Realist Perspective

Religions
The existence of the spiritual can be deduced from knowledge of the material. There is an inherent affinity between speculation and spirituality: an embrace of gaps in knowledge.
Ian McLaughlin
doaj   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

An Enduring Philosophical Agenda. Worldview Construction as a Philosophical Method [PDF]

, 2007
Is there something like a philosophical method? It seems that there are as many methods as there are philosophies. A method is any procedure employed to attain a certain end. So, before going to a method, we have to ask: what is the aim of philosophy? At
Vidal, Clément
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

The Fossils of French Spiritualism. Quentin Meillassoux – a New Path in the History of Philosophy?

Sententiae
Alain Badiou, in his “canonical” foreword to Quentin Meillassoux’s major work After Finitude: An Essay on the Necessity of Contingency (Après la finitude: Essai sur la nécessité de la contingence, 2006), claims that Meillassoux has opened up a new path ...
Pavlo Bartusiak
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Nature, Science, Bayes' Theorem, and the Whole of Reality [PDF]

, 2015
A fundamental problem in science is how to make logical inferences from scientific data. Mere data does not suffice since additional information is necessary to select a domain of models or hypotheses and thus determine the likelihood of each model or ...
Alexanian, Moorad
core  

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Dialectics and difference: against Harvey's dialectical post-Marxism [PDF]

, 1999
David Harvey`s recent book, Justice, nature and the geography of difference (JNGD), engages with a central philosophical debate that continues to dominate human geography: the tension between the radical Marxist project of recent decades and the ...
Adorno, T., Albert, M., Amin, A., Andrew Jones, Arac, J., Arthur, C., Bauman, Z., Bernstein, R., Bernstein, R., Bhabha, H., Bhabha, H., Bhaskar, R., Bogue, R., Bohm, D., Bohm, D., Boyne, R., Butler, J., Butler, J., Butler, J., Cahoone, L., Callinicos, A., Castells, M., Chambers, I., Coletti, R., Deleuze, G., Deleuze, G., Deleuze, G., Deleuze, G., Deleuze, G., Deleuze, G., Derrida, J., Derrida, J., Derrida, J., Derrida, J., Derrida, J., Derrida, J., Derrida, J., Derrida, J., Derrida, J., Diamond, I., Docherty, T., Dreyfus, H., Duncan, J., Eckersley, R., Evans, J., Foucault, M., Foucault, M., Foucault, M., Fraad, H., Game, A., Geras, N., Gergen, T., Gibson-Graham, J.K., Goodchild, P., Goodman, R., Gregory, D., Grosz, E., Habermas, J., Hall, S., Hall, S., Hampden-Turner, C., Haraway, D., Harvey, D., Harvey, D., Harvey, D., Harvey, D., Harvey, D., Harvey, D., Hegel, G., Hegel, G., Heller, A., Hirst, P., hooks, B., Hoy, D., Hutton, W., Irigaray, L., Irigaray, L., Jameson, F., Jay, M., Kaplan, E., Kariel, H., Kearney, R., Keith, M., Kellner, D., Kristeva, J., Laclau, E., Latour, B., Latour, B., Law, J., Law, J., Lechte, J., Lefebvre, H., Levins, R., Leyshon, A., Lipietz, A., Lyotard, J., Marx, K., Massey, D., McNay, L., McNay, L., Meyer, G., Norris, C., Norris, C., Ollman, B., Ollman, B., Peet, R., Pile, S., Pinkard, T.P., Reich, R., Resnick, S., Resnick, S., Resnick, S., Sayer, A., Serres, M., Shildrick, M., Simons, H., Simons, J., Smith, N., Smith, N., Soja, E., Soll, I., Spivak, G., Squires, J., Taylor, C., Thrift, N., Thrift, N., Thurow, L., White, S., Whitehead, A., Wood, D., Wood, D., Woodiwiss, A., Yeatman, A., Young, I., Young, I.   +134 more
core   +1 more source