Results 61 to 70 of about 17,208 (324)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Advances in MoS2-Based ternary nanocomposites for high-performance electrochemical energy storage

Hybrid Advances
The field of rechargeable energy storage devices is actively exploring nanostructured materials with intricate morphologies due to several advantages. The integration of nanostructured materials into various electrodes, and rechargeable systems holds the
Seyoum A. Getaneh, Abdudin G. Temam, Getachew A. Workneh, Assumpta C. Nwanya, Paul M. Ejikeme, Fabian I. Ezema   +5 more
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Redução nos custos de conformidade tributária e os investimentos no sistema público de escrituração digital – SPED no Brasil

, 2013
O Sistema Publico de Escrituracao Digital (SPED) foi desenvolvido com a intencao de prover maior integracao entre as proprias administracoes tributarias, depois entre elas e os contribuintes, atraves do uso de tecnologia e, consequentemente, de dados ...
Edson Sampaio de Lima, N. Galegale, C. H. Arima, Pedro Luiz Côrtes   +3 more
semanticscholar   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Dust emission reduction enhanced gas-to-particle conversion of ammonia in the North China Plain

Nature Communications, 2022
Liu et al. found that the formation rate of particulate ammonium is slower in the atmosphere than that observed in the laboratory, while it is sped up due to an increase in aerosol acidity driven by an emission reduction of dust in North China Plain.
Yongchun Liu, Junlei Zhan, Feixue Zheng, Boying Song, Yusheng Zhang, Wei Ma, Chenjie Hua, Jiali Xie, Xiaolei Bao, Chao Yan, Federico Bianchi, Tuukka Petäjä, Aijun Ding, Yu Song, Hong He, Markku Kulmala   +15 more
doaj   +1 more source

SPED – Sistema Público de Escrituração Digital: Percepção dos contribuintes em relação os impactos de sua adoção

, 2011
The Brazilian Government used as a model the Electronic Governments of countries such as Spain, Chile and Mexico, among others, for creating the PSDB - Public System of Digital Bookkeeping, entering into the digital era.
C. Geron, João Ricardo Finatelli, A. C. Faria, Maria do Carmo Romeiro   +3 more
semanticscholar   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

OPORTUNIDADES E DESAFIOS DO SPED NA PERSPECTIVA DOS PROFISSIONAIS CONTÁBEIS: UMA ANÁLISE SOB A ÓTICA DA TEORIA CONTINGENCIAL [PDF]

, 2021
Luciano Gomes dos Reis, VITÓRIA MARIA REIS NOVAES, LETÍCIA OLIVEIRA FERREIRA, PÂMELA LUCIANA DE MORAES   +3 more
openalex   +1 more source