Results 61 to 70 of about 16,838 (283)
, 2013 O Sistema Publico de Escrituracao Digital (SPED) foi desenvolvido com a intencao de prover maior integracao entre as proprias administracoes tributarias, depois entre elas e os contribuintes, atraves do uso de tecnologia e, consequentemente, de dados ...
Edson Sampaio de Lima +3 more
semanticscholar +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
, 2011 The Brazilian Government used as a model the Electronic Governments of countries such as Spain, Chile and Mexico, among others, for creating the PSDB - Public System of Digital Bookkeeping, entering into the digital era.
C. Geron +3 more
semanticscholar +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Revista Ambiente Contábil, 2018 O objetivo deste estudo é analisar a percepção dos contadores quanto às dificuldades de competência técnica para a implantação do Sistema Público de Escrituração Digital (SPED) nas entidades do terceiro setor.
Amanda de Lima Marques da Silva +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
User-Centric Cloud RAN: An Analytical Framework for Optimizing Area Spectral and Energy Efficiency
IEEE Access, 2018 In this article, we develop a statistical framework to quantify the area spectral efficiency (ASE) and the energy efficiency (EE) performance of a user-centric cloud based radio access network (UC-RAN) downlink.
Umair Sajid Hashmi +2 more
doaj +1 more source