Results 111 to 120 of about 3,807,781 (317)

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Efficacy of intervention programme to improve phonological sensitivity skills in Tamil speaking children who are below average scholastic performers

Journal of Child Language Acquisition and Development
Phonological awareness or phonological sensitivity refers to “the knowledge that spoken words are composed of individual sounds and the ability to manipulate them”.
Maria Jayaseelan, Amirtha Varshini M J, Ranjith Rajeswaran   +2 more
doaj   +5 more sources

Multi-domain clinical profile of an individual with cutis laxa syndrome: A case report

The Egyptian Journal of Otolaryngology
The purpose of this paper is to highlight the speech-language and audio-vestibular evaluation of an individual with Cutis Laxa Syndrome (CLS). CLS is a rare genetic disorder that primarily affects the skin, leading to a loose, saggy, and prematurely aged
Murali Subhiksha, Sairaman Thangam Ashokganesh, Prajeesh Thomas, Amulya P. Rao   +3 more
doaj   +1 more source

A clinical case of a patient with subtotal ossification of the cochlea: results of cochlear implantation using neuroimaging methods to control dynamics

Consilium Medicum
Background. Nowadays cochlear implantation (CI) is a globally recognized method of rehabilitation of people with deafness, which allows not only to improve the quality of life of the patient, but also to integrate them into the hearing environment ...
Vladimir V. Dvorianchikov, Vladislav E. Kuzovkov, Dmitrii S. Kliachko, Andrei S. Lilenko, Serafima B. Sugarova, Viktoriia A. Tanaschishina, Denis D. Kalyapin, Polina R. Kharitonova   +7 more
doaj   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Patenting Speech

SSRN Electronic Journal, 2000
Recent court cases regarding the regulation of computer software have held that such code may be protected expression under the First Amendment. Some courts have drawn on the law of copyright to conclude that because copyright protects expression, and software is copyrightable, that software must contain protected expression.
openaire   +4 more sources

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source