Results 41 to 50 of about 32,877 (298)

Modelling Speech Acts in Conversational Discourse [PDF]

open access: yes, 2005
Computational pragmatics and dialogue analysis is currently a rapid growing area of research in computational linguistics. Over the past five years or so, initiatives in modelling pragmatic aspects of dialogue have led to considerably improved spoken ...
Schiffrin, Amanda
core  

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

Approval, Praise, Compliment and Flattery in Speech Act Theory

open access: yesЗаписки з романо-германської філології, 2016
The article outlines approval, praise, compliment and flattery in terms of Speech Act Theory. The illocutionary aims of approval, praise, compliment and flattery speech acts have been differentiated.The author offers her own definitions of approval ...
Н. О. Бігунова
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

CLASSIFICATION AND WAYS OFEXPRESSION OF SUGGESTIVES

open access: yesSovremennye Issledovaniâ Socialʹnyh Problem, 2013
The article focuses on different classifications of speech acts called suggestives in the framework of speech acts theory on the basis of modern English literature.
Alexandra Michailovna Kochergan
doaj  

THE POLITENESS OF DIRECTIVE SPEECH ACTS IN SATU JAM LEBIH DEKAT ON TV ONE (PRAGMATIC APPROACH)

open access: yesPrasasti: Journal of Linguistics, 2017
This study aims to find out the types of directive speech act and politeness strategies used in Satu Jam Lebih Dekat talk show on TVOne. The method used in this article is descriptive method which describe the data systematically, factually, and ...
Nur Aini Syah, D. Djatmika, S. Sumarlam
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Speech Acts and Its Translation Accuracy in Bilingual Fables

open access: yesJ-Lalite, 2020
The study aims to analyze the type of speech act found in bilingual fables and its translation accuracy. The theory of Searle (1969) on the classification of speech act and the instrument of translation accuracy from Nababan et. al.
Usep Muttaqin   +2 more
doaj   +1 more source

Analyzing the speech actions of Imam Khomeini’s Will; based on Searle and Austin model [PDF]

open access: yesعلوم سیاسی, 2019
The aim of this study is the linguistic analysis of Imam Khomeini’s Will based on Searle and Austin theory of speech act and willing to answer to this question that According to Searle and Austin's speech act theory, what actions it will have, and what ...
ebrahim tobeyani   +2 more
doaj   +1 more source

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