Results 51 to 60 of about 32,877 (298)

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

open access: yesFEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake   +4 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

CURRENT APPROACHES TO PRAGMATICS. TOWARDS A NEW LINGUISTIC THEORY

open access: yesEIRP Proceedings, 2006
Out of all issues in the theory of language usage, the speech act theory has probably aroused the widest interest. Psychologists have suggested that the acquirement of the concepts underlying speech acts may be a prerequisite for the acquisition of ...
Liviu Mihail Marinescu
doaj  

Towards Application of Speech Act Theory to Opinion Mining

open access: yesCognitive Studies | Études cognitives, 2016
Towards the Application of Speech Act Theory to Opinion Mining The paper refers to the pragmatics’ perspective on opinion mining in Polish and English, inspired by the discrepancy between the coverage of sentiment analysis and the market demand.
Agnieszka Magdalena Pluwak
doaj   +1 more source

Revelation as a discourse of language through speech act theory

open access: yesHTS Teologiese Studies/Theological Studies, 2021
Systematic theology regards revelation as a divine discourse between God and us. However, it seems that it does not fully explain how God’s divine discourse transforms our life and what implications it has. Therefore, this article suggests investigating ‘
Anna Cho
doaj   +1 more source

The speech act of apology : a linguistic exploration of politeness orientation in British and Jordanian culture [PDF]

open access: yes, 2007
Through an investigation of the realisation patterns of apologies in British English and Jordanian Arabic, this study presents an account of politeness phenomena in Jordanian culture as compared to British culture.
Al-Adaileh, Bilal Abdal Majeed
core  

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

open access: yesFEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya   +2 more
wiley   +1 more source

Speech Act Theory and Communication Modeling

open access: yes, 2008
Since the early 1980s there has been an interest in linguistics in general and speech act theory in particular in CSCW, HCI, MIS, and IS modeling in general.
Lewis Hassell
core   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

open access: yesFEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell   +8 more
wiley   +1 more source

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