Results 61 to 70 of about 255,254 (263)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
SPEECH ACTS ANALYSIS OF DONALD TRUMP’S SPEECH
PROJECT (Professional Journal of English Education), 2019 This research deals with the types of illocutionary acts in Donald Trump’s Inaugural Speech. The research concerns with illocutionary act produced by Donald Trumps as a President of American. The aim of this research was to analyze the types of illocutionary speech act which was dominantly used in that speech.
Nura Siti Mufiah +1 more
openaire +2 more sources
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Study of effects of surgical treatment in the larynx area on the speech signal
Archives of Acoustics, 2008 The speech signal emitted by humans may be a source of useful diagnostic and prognostic information. The signal may become, indirectly by some selected parameters, an additional source of information concerning the condition of the ...
Wiesław WSZOŁEK +2 more
doaj
Paladyn, 2014 A system for recognition of emotions based on speech analysis can have interesting applications in human-robot interaction. In this paper, we carry out an exploratory study on the possibility to use a proposed methodology to recognize basic emotions ...
Rabiei Mohammad, Gasparetto Alessandro
doaj +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Assessment of Speech Intelligibility in Parkinson’s Disease Using a Speech-To-Text System
IEEE Access, 2017 Patients with Parkinson's disease (PD) may have difficulties in speaking because of reduced coordination of the muscles that control breathing, phonation, articulation, and prosody.
Giovanni Dimauro +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source