Results 81 to 90 of about 392,381 (314)
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Study of effects of surgical treatment in the larynx area on the speech signal
Archives of Acoustics, 2008 The speech signal emitted by humans may be a source of useful diagnostic and prognostic information. The signal may become, indirectly by some selected parameters, an additional source of information concerning the condition of the ...
Wiesław WSZOŁEK +2 more
doaj
Paladyn, 2014 A system for recognition of emotions based on speech analysis can have interesting applications in human-robot interaction. In this paper, we carry out an exploratory study on the possibility to use a proposed methodology to recognize basic emotions ...
Rabiei Mohammad, Gasparetto Alessandro
doaj +1 more source
Autoregressive Modelling for Linear Prediction of Ultrasonic Speech
, 2010 Ultrasonic speech is a novel research area with significant applications: as a speech-aid prosthesis for patients with voice box difficulties, silent speech interfaces, secure mode of communication in mobile phones and as a communication medium in high ...
McLoughlin, Ian V. +3 more
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E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Assessment of Speech Intelligibility in Parkinson’s Disease Using a Speech-To-Text System
IEEE Access, 2017 Patients with Parkinson's disease (PD) may have difficulties in speaking because of reduced coordination of the muscles that control breathing, phonation, articulation, and prosody.
Giovanni Dimauro +4 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Prevalence of different types of speech, language and communication disorders and speech pathology services in Australia [PDF]
, 2014 This inquiry sought to address a lack of data on the prevalence of speech, language and communication disorders in Australia. Overview The capacity to communicate verbally is fundamental to a person\u27s development and wellbeing. The ability to learn
core
A Quantitative Comparison of Epoch Extraction Algorithms for Telephone Speech
, 2019 Telephone speech is one of the degradations involved in building speech systems in practical environments. The potential use of the speech systems depends on the speech analysis algorithms that can handle different acoustic variations and degradations ...
Kadiri, Sudarsana Reddy +1 more
core +1 more source