Results 81 to 90 of about 27,180,319 (308)

The Impact of Tenapanor on Body Composition and Blood Pressure in Peritoneal Dialysis Patients: A Pilot Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Instruction Tenapanor potentially affects fluid volume and blood pressure. This study explored its effects on these parameters in patients undergoing peritoneal dialysis (PD). Methods We conducted a single‐arm, prospective observational study that enrolled 10 patients on PD with hyperphosphatemia who were newly initiated on tenapanor.
Shun Yoshida, Kengo Asahina, Keiichi Osano, Natsumi Saegusa, Kohei Yamamura, Kie Ohkoshi, Miho Shikata, Toshihisa Ishii, Makiko Konishi, Kazuya Takahashi, Kohei Uchimura, Ayumu Nakashima   +11 more
wiley   +1 more source

Machine Learning-Assisted Speech Analysis for Early Detection of Parkinson’s Disease: A Study on Speaker Diarization and Classification Techniques

Sensors
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by a range of motor and non-motor symptoms. One of the notable non-motor symptoms of PD is the presence of vocal disorders, attributed to the underlying pathophysiological changes in ...
Michele Giuseppe Di Cesare, David Perpetuini, Daniela Cardone, Arcangelo Merla   +3 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Avoiding distortions due to speech coding and transmission errors [PDF]

, 1999
We have extended our previous research on a new approach to automatic speech recognition (ASR) in the GSM environment. Instead of recognizing from the decoded speech signal, our system works from the digital speech representation used by the GSM encoder.
Valverde Albacete, Francisco José, Gallardo Antolín, Ascensión, F. Valverde-Albacete, F. Diaz-de-Maria, Díaz de María, Fernando, Díaz-de-María, Fernando, Valverde-Albacete, Francisco J., A. Gallardo-Antolin, Gallardo-Antolín, Ascensión   +8 more
core   +1 more source

Speech-based early depressive symptom screening using MAX-Net: a multi-scale autoencoder-augmented xLSTM framework

Frontiers in Psychiatry
BackgroundEarly screening for depressive symptoms lacks objective and stable biomarkers, while traditional methods based on questionnaires and subjective assessments suffer from issues such as low efficiency.
Zhiguo Zheng, Zhiguo Zheng, Lijuan Liang, Jin Zhang, Guanjun Wang, Chenyang Xue   +5 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Machine Learning-Based Screening for Obstructive Sleep Apnea Using Photographic Craniofacial and Speech-Derived Acoustic Features

Life
Obstructive sleep apnea (OSA) is a prevalent disorder for which accessible non-invasive screening approaches remain of interest. This study evaluated photographic craniofacial descriptors and speech-derived acoustic features for Apnea–Hypopnea Index (AHI)
Marissa López-Zaldivar, Sulema Torres-Ramos, Israel Román-Godínez, Daniel Hernández-Gordillo, Aurora Sofia Vázquez-Jiménez, Ricardo Antonio Salido-Ruiz   +5 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Towards a vividness in synthesized speech for audiobooks

Eesti ja Soome-ugri Keeleteaduse Ajakiri, 2019
The goal of this study was to determine which acoustic parameters are significant in differentiating the speaking styles of a narrator and that of male and female characters as voiced by a reader of audiobooks.
Hille Pajupuu, Rene Altrov, Jaan Pajupuu
doaj   +1 more source