Results 91 to 100 of about 392,381 (314)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Speech Segregation based on Pitch Track Correction and Music-Speech Classification

Advances in Electrical and Computer Engineering, 2012
A novel approach for pitch track correction and music-speech classification is proposed in order to improve the performance of the speech segregation system.
KIM, H.-G., JANG, G.-J., PARK, J.-S., KIM, J.-H., OH, Y.-H.   +4 more
doaj   +1 more source

The relationship between acoustic indices of speech motor control variability and other measures of speech performance in dysarthria

, 2012
Previous studies suggested that variability indices based on information extracted from the acoustic signal are potentially useful in assessing dysarthric speech.
Van Brenk, Frits, Lowit, Anja
core  

Comparison of glottal closure instants detection algorithms for emotional speech

, 2020
avaa julkaisu, kun artikkeli saatavillaIn production of voiced speech, epochs or glottal closure instants (GCIs) refer to the instants of significant excitation of the vocal tract.
Sudarsana Reddy Kadiri, Paavo Alku, Alku, Paavo, B. Yegnanarayana, Kadiri, Sudarsana, Yegnanarayana, Bayya   +5 more
core   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Depression and Anxiety Screening for Pregnant Women via Free Conversational Speech in Naturalistic Condition

IEEE Access
Depression and anxiety during pregnancy are critical public health concerns, impacting both maternal and fetal well-being. The onset of these mental health conditions during pregnancy can lead to adverse outcomes, such as preterm birth and impaired ...
Rafael T. Sousa, Gustavo D. M. Silva, Paula L. L. Pinto, Juliano Backes, Amanda S. Mota, Thiago M. Paixao, Maria G. S. Teixeira, Wilian H. Hisatugu, Anilton S. Garcia, Kelly S. Prado, Rodrigo S. Dias, Marco A. Galletta, Hermano Tavares   +12 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

High-quality analysis/synthesis method based on Temporal decomposition for speech modification [PDF]

, 2008
The challenge of speech modification is to flexibly modify the speech without degrading speech quality. The conventional methods are limited by their inability to flexibly control speech signals in time and frequency domains.
Takeshi Shibata, Shibata, Takeshi, Masato Akagi, Akagi, Masato, Binh Phu Nguyen, Nguyen, Binh Phu   +5 more
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Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

The effect of modality and speaking style on the discrimination of non-native phonological and phonetic contrasts in noise

, 2015
Auditory speech is difficult to discern in degraded listening conditions, however the addition of visual speech can improve perception. The Perceptual Assimilation Model [1] suggests that non-native contrasts involving a native phonological difference ...
Tyler, Michael D. (R11374), Fenwick, Sarah E. (S29421), Best, Catherine T. (R11322), Davis, Chris (R11605)   +3 more
core