Results 91 to 100 of about 27,180,319 (308)

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

Prospecting the protein design landscape

open access: yesFEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona   +4 more
wiley   +1 more source

Leveraging Deep Learning for Fine-Grained Categorization of Parkinson’s Disease Progression Levels through Analysis of Vocal Acoustic Patterns

open access: yesBioengineering
Speech impairments often emerge as one of the primary indicators of Parkinson’s disease (PD), albeit not readily apparent in its early stages. While previous studies focused predominantly on binary PD detection, this research explored the use of deep ...
Hadi Sedigh Malekroodi   +3 more
doaj   +1 more source

La contraception dans Femmes d’Aujourd’hui (1960-2010) : entre visibilisation et assignation de genre du travail procréatif

open access: yesEnfances, Familles, Générations, 2021
Research Framework: Femmes d’Aujourd’hui, Belgium’s first French-language women’s magazine, is mainly aimed at a female readership and transmits a discourse on contraception, while contributing to its construction.
Margaux Roberti-Lintermans
doaj  

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

open access: yesFEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini   +3 more
wiley   +1 more source

Study of effects of surgical treatment in the larynx area on the speech signal

open access: yesArchives of Acoustics, 2008
The speech signal emitted by humans may be a source of useful diagnostic and prognostic information. The signal may become, indirectly by some selected parameters, an additional source of information concerning the condition of the ...
Wiesław WSZOŁEK   +2 more
doaj  

What can functional transcranial Doppler ultrasonography reveal about the cerebral lateralization of writing

open access: yesFEBS Letters, EarlyView.
Which brain hemisphere controls writing? This review synthesizes all five functional transcranial Doppler studies of writing (handwriting and typing) published to date in adults and children. Right‐handers show left‐hemispheric dominance for the linguistic component of writing (written word generation), whereas findings for left‐handers remain ...
Marietta Papadatou‐Pastou
wiley   +1 more source

Mitochondrial translation and coordinated cytosolic translation in metabolic homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Mitochondrial function depends on coordinated protein production from the nuclear and mitochondrial genomes. This review highlights how cytosolic and mitochondrial translation, mRNA localization, protein import, and respiratory complex assembly are integrated to maintain mitochondrial proteostasis and function.
Boseon Kim   +4 more
wiley   +1 more source

Explaining the visual and masked-visual advantage in speech perception in noise : the role of visual phonetic cues

open access: yes, 2015
International audienceVisual enhancement of speech intelligibility, although clearly established, still resists a clear description. We attempt to contribute to solving that problem by proposing a simple account based on phonetically motivated visual ...
Aubanel, Vincent (R17640)   +2 more
core  

Estimation of the glottal source from coded telephone speech using deep neural networks [PDF]

open access: yes, 2019
Estimation of glottal source information can be performed non-invasively from speech by using glottal inverse filtering (GIF) methods. However, the existing GIF methods are sensitive even to slight distortions in speech signals under different realistic ...
Alku, Paavo   +7 more
core   +1 more source

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