Results 81 to 90 of about 322,746 (242)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Effects of hippotherapy on motor function of children with cerebral palsy: a systematic review study

Italian Journal of Pediatrics
Cerebral palsy includes a spectrum of neurodevelopmental disorders caused by brain damage, leading to impairment of movement, posture, and balance for a lifetime. There are many therapeutic interventions for cerebral palsy.
Panagiotis Plotas, Angelos Papadopoulos, Evangelia-Maria Apostolelli, Eleni Vlachou, Foteini Gazou, Ioanna Zogopoulou, Ioanna Katsaidoni, Ioanna Panagiotopoulou, Sofia Paraskevi Paparouna, Nikolina Silavou, Katerina Fragkiadaki, Eirini Tsiamaki, Sotirios Fouzas, Xenophon Sinopidis, Nikolaos Trimmis   +14 more
doaj   +1 more source

Articulatory and bottleneck features for speaker-independent ASR of dysarthric speech

, 2019
The rapid population aging has stimulated the development of assistive devices that provide personalized medical support to the needies suffering from various etiologies.
Franco, Horacio, Mitra, Vikramjit, Sivaraman, Ganesh, Yılmaz, Emre   +3 more
core   +1 more source

The working alliance in stuttering treatment: a neglected variable? [PDF]

, 2019
Background Multiple factors can influence the working alliance and treatment outcome in speech and language therapy. The ‘working alliance’ is an important concept in treatment and can be described as the degree to which a treatment dyad is engaged in
Bright F. A. S., Cox W. M., Herder C., Lambert M. J., Manning W. H., Mccauley R. J., Nordbø B., Riper C., Shapiro D. A., Sønsterud H., Ward D., Wright L., Zebrowski P. M.   +12 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Planning intervention using dynamic assessments: A case study [PDF]

, 2014
Dynamic assessments (DA) of language have been shown to be a useful addition to the battery of tests used to diagnose language impairments in children, and to evaluate their skills.
Campione JC, Ebbels S, Feuerstein R, Haywood HC, Lidz CS, Lloyd JW, Olswang L, Peña ED, Semel E   +8 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Tuberous sclerosis complex: clinical insights into communication and swallowing abilities: a case report

Journal of Rare Diseases
Background There is little published information on the presentation and response to intervention of communication and swallowing difficulties in individuals with tuberous sclerosis complex (TSC).
Louiza Voniati, Leoni Chrysanthou, Rafaella Georgiou   +2 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source