Results 21 to 30 of about 53,383 (262)

Decrypting cancer's spatial code: from single cells to tissue niches

open access: yesMolecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik   +4 more
wiley   +1 more source

Very Low Rate Scalable Speech Coding through Classified Embedded Matrix Quantization

open access: yesEURASIP Journal on Advances in Signal Processing, 2010
This paper proposes a scalable speech coding scheme using the embedded matrix quantization of the LSFs in the LPC model. For an efficient quantization of the spectral parameters, two types of codebooks of different sizes are designed and used to encode ...
Shahrokh Ghaemmaghami, Ehsan Jahangiri
doaj   +2 more sources

On the Sparse Structure of Natural Sounds and Natural Images: Similarities, Differences, and Implications for Neural Coding

open access: yesFrontiers in Computational Neuroscience, 2019
Sparse coding models of natural images and sounds have been able to predict several response properties of neurons in the visual and auditory systems. While the success of these models suggests that the structure they capture is universal across domains ...
Eric McVoy Dodds   +4 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Hammerstein Model for Speech Coding

open access: yesEURASIP Journal on Advances in Signal Processing, 2003
A nonlinear Hammerstein model is proposed for coding speech signals. Using Tsay's nonlinearity test, we first show that the great majority of speech frames contain nonlinearities (over 80% in our test data) when using 20-millisecond speech frames. Frame
Turunen Jari, Tanttu Juha T, Loula Pekka
doaj   +1 more source

Teaching Python with team‐based learning: using cloud‐based notebooks for interactive coding education

open access: yesFEBS Open Bio, EarlyView.
This study presents a novel approach to teaching Python and bioinformatics using team‐based learning and cloud‐hosted notebooks. By integrating interactive coding into biomedical education, the method improves accessibility, student engagement, and confidence—especially for those without a computing background.
Nuno S. Osório, Leonardo D. Garma
wiley   +1 more source

Research on the effectiveness of noise reduction when encoding a lossless speech signal

open access: yesНаучно-технический вестник информационных технологий, механики и оптики
In the meantime, speech coding is one of the methods to represent the digital speech signal as in possible fewer bits value and to maintain the quality and its clearness.
T. Akilan, L. Raja, U. Hariharan
doaj   +1 more source

AN EFFICIENT SPEECH GENERATIVE MODEL BASED ON DETERMINISTIC/STOCHASTIC SEPARATION OF SPECTRAL ENVELOPES

open access: yesDoklady Belorusskogo gosudarstvennogo universiteta informatiki i radioèlektroniki, 2020
The paper presents a speech generative model that provides an efficient way of generating speech waveform from its amplitude spectral envelopes. The model is based on hybrid speech representation that includes deterministic (harmonic) and stochastic ...
M. Taha   +3 more
doaj   +1 more source

Transcriptional regulation of neuropeptide receptors underlies context‐dependent adaptation in Drosophila melanogaster

open access: yesFEBS Open Bio, EarlyView.
Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu   +6 more
wiley   +1 more source

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