Results 101 to 110 of about 1,463,434 (325)

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Commentaries and post-beginners' language teaching [PDF]

, 2002
This paper suggests an approach to, and some of the potential benefits of, introducing work with commentaries into a post-beginners' language course and considers the ways in which working with commentaries can usefully enrich students' study across a ...
Robson, James
core  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Interactive articulation tale as the main form of vocal-choral work with younger preschool children [PDF]

, 2017
В статье обосновано, что эффективным средством устранения проблем речевого развития младших дошкольников является артикуляционная гимнастика как специальный цикл упражнений, направленных на развитие периферических органов речи, принимающих участие в ...
Bineyev, K. A., Zhilinskaya, S. A., Бинеев, К. А., Жилинская, С. А.   +3 more
core  

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Exploring User Satisfaction in a Tutorial Dialogue System [PDF]

, 2011
User satisfaction is a common evaluation metric in task-oriented dialogue systems, whereas tutorial dialogue systems are often evaluated in terms of student learning gain.
Campbell, Gwendolyn, Dzikovska, Myroslava O., Moore, Johanna D., Steinhauser, Natalie   +3 more
core   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Realization of Competent Approach in Pupils' Speech Development in Studying Metaphor

Russian Language Studies, 2012
The article within the frame of modern competence approach to native language teaching validates the efficiency of the key competence building in the process of metaphor studying as a polyfunctional phenomenon of mentality, the language and speech ...
A B Maximova
doaj  

SPEECH THERAPY ASSISTANCE TO CHILDREN OF MIDDLE PRESCHOOL AGE BY MEANS OF COMPUTER DIDACTIC GAMES

Інформаційні технології і засоби навчання
The article highlights the peculiarities of speech therapy assistance to children of middle preschool age using computer didactic games. All the children who were assisted had generalized underdevelopment of speech (GUS).
Viktor Hladush, Liudmyla Kotlova, Natalija Krasikova, Nadija Pavlyk   +3 more
doaj   +1 more source

Modern approaches to complex psycho-correctional work on preventing preschoolers’ stuttering

Науковий Вісник Південноукраїнського Національного Педагогічного Університету імені К. Д. Ушинського, 2019
The article investigates the theoretical foundations and practical implementation of the complex approach to psycho-corrective work on overcoming stuttering.
Lytovchenko Olha
doaj   +1 more source