Results 61 to 70 of about 1,226,261 (295)

Speaker adaptation and the evaluation of speaker similarity in the EMIME speech-to-speech translation project [PDF]

, 2010
This paper provides an overview of speaker adaptation research carried out in the EMIME speech-to-speech translation (S2ST) project. We focus on how speaker adaptation transforms can be learned from speech in one language and applied to the acoustic ...
Tokuda, Keiichi, Shannon, Matt, Shiota, Sayaka, Wester, Mirjam; id_orcid, Oura, Keiichiro, Gibson, Matthew, Hirsimaki, Teemu, Yamagishi, Junichi, King, Simon; id_orcid, Karhila, Reima, Wu, Yi-Jian, Tian, Jilei, Dines, John, Byrne, William, Saheer, Lakshmi, Liang, Hui, Kurimo, Mikko, Garner, Philip N., Guan, Yong, King, Simon, Wester, Mirjam   +20 more
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Сlassification description and exercise system in training foreign students a speciality language (levels A2 , B1, B1+)

Викладання мов у вищих навчальних закладах освіти на сучасному етапі: Міжпредметні зв'язки, 2019
Existing systems of exercises on the communicative competence formation of foreign students, learning Russian, have been considered in this article. Different approaches to the exercise classification system have been suggested.
Dubinina Lyubov, Tatiana Manyvskaia
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Postfiltering with Complex Spectral Correlations for Speech and Audio Coding

, 2018
State-of-the-art speech codecs achieve a good compromise between quality, bitrate and complexity. However, retaining performance outside the target bitrate range remains challenging.
Das, Sneha, Bäckström, Tom, Sneha Das, Tom Bäckström   +3 more
core   +1 more source

End-to-End Optimized Multi-Stage Vector Quantization of Spectral Envelopes for Speech and Audio Coding

, 2021
Spectral envelope modeling is an instrumental part of speech and audio codecs, which can be used to enable efficient entropy coding of spectral components.
Bäckström, Tom, Vali, Mohammadhassan, Mohammad Hassan Vali, Tom Bäckström   +3 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source