Results 71 to 80 of about 75,405 (258)

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Auditory and somatosensory feedback mechanisms of laryngeal and articulatory speech motor control. [PDF]

Exp Brain Res, 2022
Weerathunge HR, Voon T, Tardif M, Cilento D, Stepp CE.   +4 more
europepmc   +1 more source

Differential contributions of the two cerebral hemispheres to temporal and spectral speech feedback control

Nature Communications, 2020
Speech production is thought to rely on speech motor programs in the left cerebral hemisphere and on auditory feedback control by the right halve of the human brain.
Mareike Floegel, Susanne Fuchs, Christian A. Kell   +2 more
doaj   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Speech motor control and orofacial point pressure sensation in adults with ADHD. [PDF]

Neurosci Lett, 2021
Etter NM, Cadely FA, Peters MG, Dahm CR, Neely KA.   +4 more
europepmc   +1 more source

Research Paper: Investigation of Acoustic Characteristics of Speech Motor Control in Children Who Stutter and Children Who Do Not Stutter

Journal of Rehabilitation, 2016
Objective Stuttering is a developmental disorder of speech fluency with unknown causes. One of the proposed theories in this field is deficits in speech motor control that is associated with damaged control, timing, and coordination of the speech muscles.
Fatemeh Fakar Gharamaleki, Mohammad Rahim Shahbodaghi, Ali Jahan, Shohre Jalayi   +3 more
doaj  

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Speech-induced suppression and vocal feedback sensitivity in human cortex

eLife
Across the animal kingdom, neural responses in the auditory cortex are suppressed during vocalization, and humans are no exception. A common hypothesis is that suppression increases sensitivity to auditory feedback, enabling the detection of vocalization
Muge Ozker, Leyao Yu, Patricia Dugan, Werner Doyle, Daniel Friedman, Orrin Devinsky, Adeen Flinker   +6 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Validation of an Acoustic-Based Framework of Speech Motor Control: Assessing Criterion and Construct Validity Using Kinematic and Perceptual Measures. [PDF]

J Speech Lang Hear Res, 2021
Rowe HP, Stipancic KL, Lammert AC, Green JR.   +3 more
europepmc   +1 more source