Results 41 to 50 of about 22,657 (266)

Whole-word measures and the speech production of typically developing Dutch children

Clinical Linguistics & Phonetics, 2019
In this study, the phonological whole-word measure Phonological Mean Length of Utterance was applied to identify stages in the phonological acquisition of Dutch children. Ninety spontaneous speech samples of 47 typically developing Dutch children from a previous study were examined.
Mieke Beers, Marianne Rodenburg-Van Wee, Ellen Gerrits   +2 more
openaire   +2 more sources

Measurement of Voice Onset Time in Maxillectomy Patients

The Scientific World Journal, 2014
Objective speech evaluation using acoustic measurement is needed for the proper rehabilitation of maxillectomy patients. For digital evaluation of consonants, measurement of voice onset time is one option.
Mariko Hattori, Yuka I. Sumita, Hisashi Taniguchi   +2 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Impacto do uso do SpeechEasy® nos parâmetros acústicos e motores da fala de indivíduos com gagueira

Audiology: Communication Research
Objetivo Investigar variações nas habilidades motoras da fala em adultos com e sem gagueira, utilizando o dispositivo de alteração do feedback auditivo SpeechEasy®.
Ana Paula Ritto, Fabiola Staróbole Juste, Claudia Regina Furquim de Andrade   +2 more
doaj   +1 more source

Vocal Parameters of Adults with Down Syndrome in Zahedan /Iran [PDF]

Journal of Kerman University of Medical Sciences, 2009
Background & Aims: Previous studies have indicated significant differences in vocal parameters between children with Down syndrome and normal children, but there are challenges about these differences. In this study vocal parameters and Maximum Phonation
M.S Sif panahi, T Salmalian, M Dehghan
doaj  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

“Product” Versus “Process” Measures in Assessing Speech Recognition Outcomes in Adults With Cochlear Implants [PDF]

Otology & Neurotology, 2018
Hypotheses: 1) When controlling for age in postlingual adult cochlear implant (CI) users, information-processing functions, as assessed using “process” measures of working memory capacity, inhibitory control, information-processing speed, and fluid reasoning, will predict traditional “product” outcome measures of speech ...
Aaron C, Moberly, Irina, Castellanos, Kara J, Vasil, Oliver F, Adunka, David B, Pisoni   +4 more
openaire   +2 more sources

La sílaba en la producción del habla de individuos con afasia de Broca The syllable in production of speech for individuals with Broca's aphasia

Revista CEFAC, 2008
OBJETIVOS: analizar los sonidos [+ líquidos] en dos tipos de estructura silábica en la producción de habla de 35 hablantes de español con afasia de Broca con el fin de determinar si dichas estructuras se conservan o se pierden.
Hernán Martínez Matos
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source