Results 71 to 80 of about 9,034,800 (304)

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Impacts of jaw surgery on speech in Class III patients

Nature Communications
Patients with severe Dentofacial Disharmony such as Class III underbites have a twentyfold increased prevalence of speech disorders. To understand the longitudinal effects of corrective jaw surgery on speech, a prospective observational cohort study was ...
Erika Rezende Silva, Christine Sirna Bode, Griffin Lowry, Jeannene Matthews, Thao Quynh Ngo, Ayumi Shoji, Jialiu Xie, Aliha Younus, Chelsea D’Abreo, Timothy Turvey, George Blakey, Ray White, David Zajac, Jeff Mielke, Laura Anne Jacox   +14 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Systematic studies of modified vocalization: the effect of speech rate on speech production measures during metronome‐paced speech in persons who stutter [PDF]

International Journal of Language & Communication Disorders, 2013
AbstractBackgroundMetronome‐paced speech results in the elimination, or substantial reduction, of stuttering moments. The cause of fluency during this fluency‐inducing condition is unknown. Several investigations have reported changes in speech pattern characteristics from a control condition to a metronome‐paced speech condition, but failure to ...
openaire   +2 more sources

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Numerical investigation of effects of tongue articulation and velopharyngeal closure on the production of sibilant [s]

Scientific Reports, 2022
A numerical simulation of sibilant /s/ production with the realistically moving vocal tract was conducted to investigate the flow and acoustic characteristics during the articulation process of velopharyngeal closure and tongue movement. The articulation
HsuehJui Lu, Tsukasa Yoshinaga, ChungGang Li, Kazunori Nozaki, Akiyoshi Iida, Makoto Tsubokura   +5 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

A Speech Production Model for Radar: Connecting Speech Acoustics with Radar-Measured Vibrations

Millimeter Wave (mmWave) radar has emerged as a promising modality for speech sensing, offering advantages over traditional microphones. Prior works have demonstrated that radar captures motion signals related to vocal vibrations, but there is a gap in the understanding of the analytical connection between radar-measured vibrations and acoustic speech ...
Lenz, Isabella, Rong, Yu, Bliss, Daniel, Liss, Julie, Berisha, Visar   +4 more
openaire   +2 more sources