Results 81 to 90 of about 2,396,973 (306)

Improved subword modeling for WFST-based speech recognition [PDF]

, 2017
Because in agglutinative languages the number of observed word forms is very high, subword units are often utilized in speech recognition. However, the proper use of subword units requires careful consideration of details such as silence modeling ...
Virpioja, Sami, Mikko Kurimo, Kurimo, Mikko, Smit, Peter, Peter Smit, Sami Virpioja   +5 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Likelihood-Maximizing-Based Multiband Spectral Subtraction for Robust Speech Recognition

EURASIP Journal on Advances in Signal Processing, 2009
Automatic speech recognition performance degrades significantly when speech is affected by environmental noise. Nowadays, the major challenge is to achieve good robustness in adverse noisy conditions so that automatic speech recognizers can be used in ...
Bagher BabaAli, Hossein Sameti, Mehran Safayani   +2 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Hybrid Models for Automatic Speech Recognition: a Comparison of Classical ANN and Kernel Based Methods [PDF]

, 2007
Support Vector Machines (SVMs) are state-of-the-art methods for machine learning but share with more classical Artificial Neural Networks (ANNs) the difficulty of their application to input patterns of non-fixed dimension.
Peláez-Moreno, Carmen, Díaz de María, Fernando, Díaz-de-María, Fernando, Peláez Moreno, Carmen, Solera Ureña, R., García-Moral, Ana I.   +5 more
core   +2 more sources

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Assessment and analysis of accents in air traffic control speech: a fusion of deep learning and information theory

Frontiers in Neurorobotics
IntroductionEnhancing the generalization and reliability of speech recognition models in the field of air traffic control (ATC) is a challenging task. This is due to the limited storage, difficulty in acquisition, and high labeling costs of ATC speech ...
Weijun Pan, Jian Zhang, Yumei Zhang, Peiyuan Jiang, Shuai Han   +4 more
doaj   +1 more source