Results 61 to 70 of about 154,869 (269)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Automatic Speech Recognition with Very Large Conversational Finnish and Estonian Vocabularies

, 2017
Today, the vocabulary size for language models in large vocabulary speech recognition is typically several hundreds of thousands of words. While this is already sufficient in some applications, the out-of-vocabulary words are still limiting the usability
Virpioja, Sami, Mikko Kurimo, Kurimo, Mikko, Seppo Enarvi, Enarvi, Seppo, Smit, Peter, Peter Smit, Sami Virpioja   +7 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

An Agent-based Framework for Speech Investigation

, 2013
The 9th International Conference on Speech Communication and Technology (Interspeech 2005), Lisbon, Portugal, September, 2005This paper presents a novel agent-based framework for investigating speech recognition which combines statistical data and ...
O'Hare, G. M. P. (Greg M. P.), Carson-Berndsen, Julie, Walsh, Michael, O\u27Hare, G. M. P. (Greg M. P.)   +3 more
core  

TinyML for Speech Recognition

2025 IEEE 49th Annual Computers, Software, and Applications Conference (COMPSAC)
We train and deploy a quantized 1D convolutional neural network model to conduct speech recognition on a highly resource-constrained IoT edge device. This can be useful in various Internet of Things (IoT) applications, such as smart homes and ambient assisted living for the elderly and people with disabilities, just to name a few examples.
Andrew Barovic, Armin Moin
openaire   +2 more sources

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

A new manifold representation for visual speech recognition [PDF]

, 2007
In this paper, we propose a new manifold representation for visual speech recognition. The developed system consists of three main steps: a. Lip extraction from input video data. b.
D. Yu, A. Sutherland, Dahai Yu, Ovidiu Ghita, P.F. Whelan, Sutherland, Alistair, Paul F. Whelan, Ghita, Ovidiu, O. Ghita, Alistair Sutherland, Yu, Dahai, Whelan, Paul F.   +11 more
core   +1 more source

Visual Speech Recognition

, 2011
Lip reading is used to understand or interpret speech without hearing it, a technique especially mastered by people with hearing difficulties. The ability to lip read enables a person with a hearing impairment to communicate with others and to engage in social activities, which otherwise would be difficult.
openaire   +3 more sources

In-Materia Speech Recognition

CoRR
With the rise of decentralized computing, as in the Internet of Things, autonomous driving, and personalized healthcare, it is increasingly important to process time-dependent signals at the edge efficiently: right at the place where the temporal data are collected, avoiding time-consuming, insecure, and costly communication with a centralized ...
Mohamadreza Zolfagharinejad, Julian Büchel, Lorenzo Cassola, Sachin Kinge, Syed Ghazi Sarwat, Abu Sebastian, Wilfred G. van der Wiel   +6 more
openaire   +2 more sources

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source