Results 51 to 60 of about 6,479,089 (255)
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Speed-Accuracy Tradeoff-based Deep Cognitive Diagnostic Model [PDF]
Jisuanji kexueIn intelligent education,cognitive diagnosis analyzes students' learning behavior data to understand their cognitive state.Existing cognitive diagnostic models based on deep learning methods assume by default that students have enough reaction time to ...
CHENG Yan, ZHOU Ziwei, MA Mingyu, LIN Qinglong, ZHAN Yongxin, WAN Lingfeng
doaj +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Trade-off between predictive accuracy and explainability.
, 2018 Trade-off between predictive accuracy and explainability.
Mark Tacey (5510126) +12 more
core +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
The matrix reasoning item bank (MaRs-IB): novel, open-access abstract reasoning items for adolescents and adults [PDF]
Royal Society Open Science, 2019 Existing non-verbal ability tests are typically protected by copyright, preventing them from being freely adapted or computerized. Working towards an open science framework, we provide 80 novel, open-access abstract reasoning items, an online ...
Gabriele Chierchia +5 more
doaj +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
No trade-off between learning speed and associative flexibility in bumblebees: a reversal learning test with multiple colonies [PDF]
, 2012 Potential trade-offs between learning speed and memory-related performance could be important factors in the evolution of learning. Here, we test whether rapid learning interferes with the acquisition of new information using a reversal learning paradigm.
Raine, Nigel E. +8 more
core +1 more source
Role of frontal cortices in the speed accuracy trade-off
, 2022 Study applying tDCS to left prefrontal cortex and superior medial frontal cortex to investigate the causal role of these regions in the speed accuracy trade off (SAT).
Jennifer Seeto, Hannah Filmer
core +1 more source
Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley +1 more source