Results 111 to 120 of about 6,364 (304)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Affordable Road Obstacle Detection and Active Suspension Control Using Inertial and Motion Sensors

World Electric Vehicle Journal
The electrification trend characterizing the current automotive industry creates opportunities for the implementation of innovative functionalities, enhancing aspects of energy efficiency and vehicle dynamics.
Andrew Valdivieso-Soto, Gennaro Sorrentino, Giulia Moscone, Renato Galluzzi, Nicola Amati   +4 more
doaj   +1 more source

Simulasi Tegangan Pada Pengaruh Putaran Roda terhadap Speed Bump Menggunakan Metode FEM

, 2018
The interaction between tires with road surface is very important because it can reduce the risk of accidents due to damage to the tire. This research was investigated the stress distribution as a result on pressure of tires rolling across speed bump ...
M.B. Haryono, Hidayat, R., Haryono, M.B., R. Hidayat   +3 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Effects of Structure Parameters on Static Performance of Gas Foil Bearings Based on a New Fully Coupled Elastic–Aerodynamic Model

Lubricants
Accurately predicting the performance of gas foil bearings (GFBs) is important. This paper presents a new fully coupled elastic–aerodynamic model for analyzing the static performance of gas foil journal bearings (GFJBs).
Pengjing Ding, Yang Hu, Xiaojing Wang, Yonggang Meng   +3 more
doaj   +1 more source

Speed Bump Systems: Visual tools for locating the viewer

, 2007
Catalogue essay published for exhibition by Dirk Yates: ‘Speed Bump Systems’, Metro Arts, Brisbane.
Paine, Ashley
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Design and Test of an Energy-Saving Bionic-Inspired Rotary Blade: A Study on Power Consumption and Soil Surface Quality

Agriculture
To reduce the power consumption of rotary tillage and enhance the operational quality of rotary tillage, a rotary blade that imitates the surface of a pufferfish was designed through reverse engineering.
Yue Qin, Yunpeng Gao, Chenggong Xie, Jiarui Tong, Qi Wang, Xin Feng   +5 more
doaj   +1 more source

PERANCANGAN MODEL SISTEM DETEKSI DAN ESTIMASI JARAK SPEED BUMP UNTUK KENDARAAN OTONOM MENGGUNAKAN ALGORITMA DEEP LEARNING [PDF]

Sistem deteksi speed bump merupakan komponen penting yang harus dimiliki oleh kendaraan otonom level 3 dan 4, sesuai instruksi dari US National Highway Traffic Safety Administration (NHTSA).
Rahmawati, -
core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source