Results 91 to 100 of about 87,608 (299)

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Application of a compliant foil bearing for the thrust force estimation in the single stage radial blower

Open Engineering, 2015
The paper presents the application of a compliant foil bearing for estimation of the thrust force in a single stage radial blower under operational conditions. The bump foil of the thrust bearing behaves as a nonlinear spring. The knowledge of the spring
Łagodzinski Jakub, Miazga Kacper, Musiał Izabela   +2 more
doaj   +1 more source

The Dynamics and Afterglow Radiation of Gamma-Ray Bursts. I. Constant Density Medium

, 2009
Direct multi-dimensional numerical simulation is the most reliable approach for calculating the fluid dynamics and observational signatures of relativistic jets in gamma-ray bursts (GRBs). We present a two-dimensional relativistic hydrodynamic simulation
Andrew MacFadyen, Ayal, Barkov, Berger, Berger, Blandford, Bucciantini, Cannizzo, Chevalier, Chevalier, Cohen, Dai, Dai, Dalal, Frail, Frail, Frail, Fryxell, Granot, Granot, Granot, Granot, Granot, Grupe, Gruzinov, Gruzinov, Harrison, Harrison, Kumar, Levinson, Li, Livio, MacFadyen, Medvedev, Meszaros, Meszaros, Meszaros, Mignone, Morsony, Nakar, Nishikawa, Nousek, O'Brien, Paczynski, Panaitescu, Panaitescu, Panaitescu, Perna, Ramirez-Ruiz, Rhoads, Rhoads, Sari, Sari, Sari, Soderberg, Spitkovsky, Stanek, Synge, Uzdensky, Uzdensky, Wang, Waxman, Waxman, Weiqun Zhang, Wijers, Zeh, Zhang, Zhang, Zhang, Zhang, Zhang, Zhang   +71 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Manual wheelchair downhill stability: an analysis of factors affecting tip probability

Journal of NeuroEngineering and Rehabilitation, 2018
Background For people who use manual wheelchairs, tips and falls can result in serious injuries including bone fractures, concussions, and traumatic brain injury.
Louise Thomas, Jaimie Borisoff, Carolyn J. Sparrey   +2 more
doaj   +1 more source

Informational Inequality: How High Frequency Traders Use Premier Access to Information to Prey on Institutional Investors [PDF]

, 2016
In recent months, Wall Street has been whipped into a frenzy following the March 31st release of Michael Lewis’ book “Flash Boys.” In the book, Lewis characterizes the stock market as being rigged, which has institutional investors and outside observers ...
Adrian, Jacob
core   +1 more source

Rossby Wave Instability and Long-Term Evolution of Dead Zones in Protoplanetary Discs

, 2015
The physical mechanism of angular momentum transport in poorly ionized regions of protoplanetary discs, the dead zones (DZs), is not understood. The presence of a DZ naturally leads to conditions susceptible to the Rossby wave instability (RWI), which ...
Lai, Dong, Meheut, Heloise, Miranda, Ryan   +2 more
core   +3 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Three-dimensional numerical simulation of a vortex ring impacting a bump

Theoretical and Applied Mechanics Letters, 2014
A vortex ring impinging on a three-dimensional bump is studied using large eddy simulation for a Reynolds number Re = 4 × 104 based on the initial translation speed and diameter of the vortex ring.
Heng Ren, Changyue Xu
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source