Results 81 to 90 of about 6,364 (304)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Manual wheelchair downhill stability: an analysis of factors affecting tip probability

Journal of NeuroEngineering and Rehabilitation, 2018
Background For people who use manual wheelchairs, tips and falls can result in serious injuries including bone fractures, concussions, and traumatic brain injury.
Louise Thomas, Jaimie Borisoff, Carolyn J. Sparrey   +2 more
doaj   +1 more source

PENGARUH PEMASANGAN SPEED BUMP TERHADAP KECEPATAN KENDARAAN DI RUAS JALAN LINGKAR SELATAN (UNIVERSITAS ANDALAS) [PDF]

, 2021
Perkembangan teknologi yang semakin maju pada kendaraan bermotor yang menyebabkan angka kecelakaan lalu lintas semakin bertambah. Hal ini dikarenakan pengguna kendaraan bisa memacu kecepatan kendaraannya dengan kecepatan tinggi.
Nadya, Ayatri
core  

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Application of a compliant foil bearing for the thrust force estimation in the single stage radial blower

Open Engineering, 2015
The paper presents the application of a compliant foil bearing for estimation of the thrust force in a single stage radial blower under operational conditions. The bump foil of the thrust bearing behaves as a nonlinear spring. The knowledge of the spring
Łagodzinski Jakub, Miazga Kacper, Musiał Izabela   +2 more
doaj   +1 more source

Electrical characterization of bump-less high speed channel on silicon, organic and glass interposer

, 2014
In this paper, we propose the structure of bump-less high speed channel on interposer in through-via based 2.5D or 3D integrated circuit (IC). Electrical characterization of the proposed structure is analyzed by simulation in the frequency-and time ...
Kim, Hyungsoo, Kim, Kiyeong, Park, Kunwoo, Jaemin Lim, Lee, Hyunsuk, Hyungsoo Kim, Lim, Jaemin, Daniel H. Jung, Heegon Kim, Jung, Daniel Hyunsuk, Kim, Jonghoon J, Kim, Joungho, Choi, Sumin, Sumin Choi, Kim, Hee-Gon, Hyunsuk Lee, Kunwoo Park, Jonghoon J. Kim, Joungho Kim, Kiyeong Kim   +19 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Three-dimensional numerical simulation of a vortex ring impacting a bump

Theoretical and Applied Mechanics Letters, 2014
A vortex ring impinging on a three-dimensional bump is studied using large eddy simulation for a Reynolds number Re = 4 × 104 based on the initial translation speed and diameter of the vortex ring.
Heng Ren, Changyue Xu
doaj   +1 more source