Results 81 to 90 of about 87,608 (299)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Speed bump detection on LiDAR point cloud for autonomous vehicles

Journal of Electrical Systems and Information Technology
Speed bump detection is paramount for ensuring the safe and comfortable operation of autonomous vehicles while complying with traffic regulations. Detecting speed bumps well in advance enables timely brake application, ensuring a smooth travel experience
Bhaskar Anand, Rajalakshmi Pachamuthu
doaj   +1 more source

Rotor Dynamic Characteristics Supported by Multi-Pad Bump Foil Gas Bearings

Lubricants
Bump foil gas bearings (BFGBs) play an important role in high-speed turbomachinery. However, most studies on the dynamic characteristics of BFGBs focus on a one-pad structure composed of a bump foil and a top foil. This paper considers the multi-pad foil
Lei Zhao, Hongyang Hu, Changlin Li, Jingquan Zhao   +3 more
doaj   +1 more source

Experimental investigation of unsteadiness in transonic shock boundary layer interaction [PDF]

, 2010
Transonic shock wave/boundary layer interaction over a wall-mounted bump was investigated with specific focus on shock wave unsteadiness and identification of its source. A large separation bubble resulted of an interaction driven by a flow characterized
Bénard, Emmanuel, Huang, Jui-Che, Raghunathan, Srinivasan   +2 more
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Revolution-bump mapping with texture function adjustment according to the geometry of the revolved object

Journal of Graphic Engineering and Design
Nowadays, 3D computer graphics are firmly anchored in our daily lives, extending across a multitude of distinct fields. Although each field follows its specific objectives, two major objectives are taken into consideration: realism and rendering speed ...
Anouar Ragragui, Adnane Ouazzani Chahdi, Amina Arbah, Hicham El Moubtahij, Akram Halli, Khalid Satori   +5 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Dynamical Synapses Enhance Neural Information Processing: Gracefulness, Accuracy and Mobility

, 2012
Experimental data have revealed that neuronal connection efficacy exhibits two forms of short-term plasticity, namely, short-term depression (STD) and short-term facilitation (STF).
C. C. Alan Fung, Cortes J. M., Dayan P., He Wang, K. Y. Michael Wong, Romani S., Si Wu, Welling M.   +7 more
core   +2 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source